The Rett syndrome-causing MECP2 T158A mutant is unable to bi...

created [InstanceEdit:9023460] Orlic-Milacic, Marija, 2017-09-27
dbId 9023463
displayName The Rett syndrome-causing MECP2 T158A mutant is unable to bi...
modified [InstanceEdit:9605003] Orlic-Milacic, Marija, 2018-04-06
schemaClass Summation
text The Rett syndrome-causing MECP2 T158A mutant is unable to bind to 5mC-DNA (DNA containing 5-methylcytosine) and has reduced protein stability. While MECP2 T158A can bind to the SIN3A complex, it is unable to bind to the promoter of the brain-derived neurotrophic factor (BDNF) gene (Goffin et al. 2012).
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