Reactome | PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)

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PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) Show undefined attributes

authored	[InstanceEdit:9023203] May, Bruce, 2017-09-25
catalystActivity	[CatalystActivity:378987] serine-type endopeptidase activity of PC1:calcium cofactor [secretory granule lumen]
category	transition
compartment	[Compartment:1462052] secretory granule lumen
created	[InstanceEdit:9023176] May, Bruce, 2017-09-27
dbId	9023196
deleted	[Deleted:9608312] Deletion of instance: 265179
displayName	PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)
edited	[InstanceEdit:9023203] May, Bruce, 2017-09-25
eventOf	[Pathway:R-HSA-264876] Insulin processing - Homo sapiens
followingEvent	[Reaction:R-HSA-9023163] Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) - Homo sapiens
inferredFrom	[Reaction:R-NUL-9023165] Pcsk1 (rat) cleaves human proinsulin to yield Insulin(25-56) and Insulin(57-110) - Homo sapiens [BlackBoxEvent:R-MMU-216806] Processing of Proinsulin to Insulin - Mus musculus
input	[Complex:R-HSA-265073] 6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] [SimpleEntity:R-ALL-351603] H2O [secretory granule lumen]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:378980] Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene [LiteratureReference:445541] Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency [LiteratureReference:445479] Direct identification of prohormone conversion site in insulin-secreting cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)
output	[Complex:R-HSA-9023182] 6x2xHC-INS(25-56):4xHC-INS(57-110):2xZn2+:1xCa2+ [secretory granule lumen]
precedingEvent	[BlackBoxEvent:R-HSA-265153] Proinsulin:Zinc:Calcium complex translocates to immature secretory granule - Homo sapiens
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9023196
summation	[Summation:9023158] PCSK1 cleaves C-terminal to arginine-56 in proinsulin to yie...

Referrals

(replacementInstances)	[Deleted:9608312] Deletion of instance: 265179
(hasEvent)	[Pathway:R-HSA-264876] Insulin processing
(precedingEvent)	[Reaction:R-HSA-9023163] Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)
(inferredTo)	[BlackBoxEvent:R-MMU-216806] Processing of Proinsulin to Insulin [Reaction:R-NUL-9023165] Pcsk1 (rat) cleaves human proinsulin to yield Insulin(25-56) and Insulin(57-110)

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