Reactome | Processing of Proinsulin to Insulin

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Processing of Proinsulin to Insulin Show undefined attributes

authored	[InstanceEdit:216805] May, B, 2008-03-22 08:26:49
catalystActivity	[CatalystActivity:216665] zinc ion transmembrane transporter activity of Zinc Transporter8 (ZnT8) [Golgi membrane] [CatalystActivity:216803] serine-type endopeptidase activity of Pcsk1 [secretory granule lumen] [CatalystActivity:216789] serine-type endopeptidase activity of Convertase PC2 (in immature granule) [secretory granule lumen] [CatalystActivity:216802] peptidase activity of Carboxypeptidase E (in immature granule) [secretory granule membrane]
category	omitted
compartment	[Compartment:1462052] secretory granule lumen [Compartment:216813] secretory granule membrane [Compartment:20699] Golgi membrane
created	[InstanceEdit:216805] May, B, 2008-03-22 08:26:49
dbId	216806
displayName	Processing of Proinsulin to Insulin
edited	[InstanceEdit:216805] May, B, 2008-03-22 08:26:49
followingEvent	[BlackBoxEvent:R-MMU-216852] Insulin secretory granule translocates to cell cortex - Mus musculus
input	[Complex:R-MMU-216793] Proinsulin-Zinc-Calcium complex [secretory granule lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:264278] Zinc-ligand interactions modulate assembly and stability of the insulin hexamer -- a review [LiteratureReference:264281] The role of assembly in insulin's biosynthesis [LiteratureReference:264356] In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion [LiteratureReference:264343] Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3 [LiteratureReference:264347] The proprotein convertases [LiteratureReference:2684519] Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice [LiteratureReference:8931827] SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed ? cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Processing of Proinsulin to Insulin
orthologousEvent	[Reaction:R-HSA-9023178] PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) - Homo sapiens [Reaction:R-HSA-9023163] Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) - Homo sapiens [Reaction:R-HSA-9023196] PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) - Homo sapiens
output	[DefinedSet:R-MMU-216653] C peptide [secretory granule lumen] [Complex:R-MMU-216790] Insulin:Zinc:Calcium [secretory granule lumen]
regulatedBy	[Requirement:R-MMU-8949114] Requirement by 'Sorcs1 [Golgi membrane]'
regulationReference	[RegulationReference:9641766] Requirement by 'Sorcs1 [Golgi membrane]' SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed ? cells
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-216806
summation	[Summation:264212] Proinsulin in proinsulin-zinc-calcium complexes is cleaved b...

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(precedingEvent)

[BlackBoxEvent:R-MMU-216852] Insulin secretory granule translocates to cell cortex

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