Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
MECP2 regulates neuronal receptors and channels
Show undefined attributes
Go to Details
authored
[InstanceEdit:9024208] Orlic-Milacic, Marija, 2017-10-02
created
[InstanceEdit:9022698] Orlic-Milacic, Marija, 2017-09-25
dbId
9022699
displayName
MECP2 regulates neuronal receptors and channels
edited
[InstanceEdit:9615799] Orlic-Milacic, Marija, 2018-08-08
eventOf
[Pathway:R-HSA-8986944] Transcriptional Regulation by MECP2 - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-9022359] MECP2:SIN3A complex binds GRIA2 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9022365] GRIA2 gene expression is inhibited by MECP2:SIN3A complex - Homo sapiens
[Reaction:R-HSA-9006490] MECP2 binds the GRIN2A gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9006507] GRIN2A gene expression is stimulated by MECP2 - Homo sapiens
[Reaction:R-HSA-9020504] MECP2 binds GRIN2B gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9020513] GRIN2B gene expression is inhibited by MECP2 - Homo sapiens
[Reaction:R-HSA-9021954] MECP2 binds OPRK1 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9021951] OPRK1 gene expression is stimulated by MECP2 - Homo sapiens
[Reaction:R-HSA-9017954] MECP2:SIN3A complex binds OPRM1 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9017921] OPRM1 gene expression is repressed by MECP2 - Homo sapiens
[Reaction:R-HSA-9021946] MECP2 binds GPRIN1 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9021948] GPRIN1 gene expression is stimulated by MECP2 - Homo sapiens
[Reaction:R-HSA-8986943] MECP2 binds MET gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-8986940] MET gene transcription is stimulated by MECP2 - Homo sapiens
[Reaction:R-HSA-9023346] MECP2 binds NOTCH1 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9023345] NOTCH1 gene expression is inhibited by MECP2 - Homo sapiens
[Reaction:R-HSA-9005988] MECP2 binds the TRPC3 gene - Homo sapiens
[BlackBoxEvent:R-HSA-9005994] TRPC3 gene transcription is stimulated by MECP2 - Homo sapiens
[Reaction:R-HSA-9022175] MECP2:CREB1 complex binds SLC2A3 gene - Homo sapiens
[BlackBoxEvent:R-HSA-9022186] SLC2A3 gene expression is stimulated by MECP2:CREB1 complex - Homo sapiens
[Reaction:R-HSA-9022734] MECP2 binds FKBP5 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9022728] FKBP5 gene expression is inhibited by MECP2 - Homo sapiens
[Reaction:R-HSA-9023538] MECP2 binds PTPN1 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9023549] PTPN1 gene expression is inhibited by MECP2 - Homo sapiens
[Reaction:R-HSA-9006588] MECP2 binds the PTPN4 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9006585] PTPN4 gene expression is stimulated by MECP2 - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9021089] MeCP2, a key contributor to neurological disease, activates and represses transcription
[LiteratureReference:9021892] Creb1-Mecp2-(m)CpG complex transactivates postnatal murine neuronal glucose transporter isoform 3 expression
[LiteratureReference:9017785] MeCP2 deficiency disrupts axonal guidance, fasciculation, and targeting by altering Semaphorin 3F function
[LiteratureReference:9006491] NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2
[LiteratureReference:9017905] Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor
[LiteratureReference:9017945] Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells
[LiteratureReference:9023536] PTP1B inhibition suggests a therapeutic strategy for Rett syndrome
[LiteratureReference:9020521] Activity-dependent NR2B expression is mediated by MeCP2-dependent epigenetic regulation
[LiteratureReference:9011208] Methyl-CpG Binding Protein 2 (Mecp2) Regulates Sensory Function Through Sema5b and Robo2
[LiteratureReference:9006006] Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice
[LiteratureReference:9023137] Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway
[LiteratureReference:9022718] Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome
[LiteratureReference:8986955] Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome
[LiteratureReference:9022360] The Rett syndrome protein MeCP2 regulates synaptic scaling
[LiteratureReference:9017942] Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome
[LiteratureReference:9022719] Mecp2-null mice provide new neuronal targets for Rett syndrome
[LiteratureReference:9006581] Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
MECP2 regulates neuronal receptors and channels
releaseDate
2018-09-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9608119] Krishnaraj, Rahul, 2018-08-07
[InstanceEdit:9608114] Christodoulou, John, 2018-08-07
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9022699
summation
[Summation:9023905] Receptors directly transcriptionally regulated by MECP2 incl...
Referrals
(hasEvent)
[Pathway:R-HSA-8986944] Transcriptional Regulation by MECP2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text