Reactome | MECP2 regulates neuronal receptors and channels

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MECP2 regulates neuronal receptors and channels Show undefined attributes

authored	[InstanceEdit:9024208] Orlic-Milacic, Marija, 2017-10-02
created	[InstanceEdit:9022698] Orlic-Milacic, Marija, 2017-09-25
dbId	9022699
displayName	MECP2 regulates neuronal receptors and channels
edited	[InstanceEdit:9615799] Orlic-Milacic, Marija, 2018-08-08
eventOf	[Pathway:R-HSA-8986944] Transcriptional Regulation by MECP2 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9022359] MECP2:SIN3A complex binds GRIA2 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9022365] GRIA2 gene expression is inhibited by MECP2:SIN3A complex - Homo sapiens [Reaction:R-HSA-9006490] MECP2 binds the GRIN2A gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9006507] GRIN2A gene expression is stimulated by MECP2 - Homo sapiens [Reaction:R-HSA-9020504] MECP2 binds GRIN2B gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9020513] GRIN2B gene expression is inhibited by MECP2 - Homo sapiens [Reaction:R-HSA-9021954] MECP2 binds OPRK1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9021951] OPRK1 gene expression is stimulated by MECP2 - Homo sapiens [Reaction:R-HSA-9017954] MECP2:SIN3A complex binds OPRM1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9017921] OPRM1 gene expression is repressed by MECP2 - Homo sapiens [Reaction:R-HSA-9021946] MECP2 binds GPRIN1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9021948] GPRIN1 gene expression is stimulated by MECP2 - Homo sapiens [Reaction:R-HSA-8986943] MECP2 binds MET gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8986940] MET gene transcription is stimulated by MECP2 - Homo sapiens [Reaction:R-HSA-9023346] MECP2 binds NOTCH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9023345] NOTCH1 gene expression is inhibited by MECP2 - Homo sapiens [Reaction:R-HSA-9005988] MECP2 binds the TRPC3 gene - Homo sapiens [BlackBoxEvent:R-HSA-9005994] TRPC3 gene transcription is stimulated by MECP2 - Homo sapiens [Reaction:R-HSA-9022175] MECP2:CREB1 complex binds SLC2A3 gene - Homo sapiens [BlackBoxEvent:R-HSA-9022186] SLC2A3 gene expression is stimulated by MECP2:CREB1 complex - Homo sapiens [Reaction:R-HSA-9022734] MECP2 binds FKBP5 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9022728] FKBP5 gene expression is inhibited by MECP2 - Homo sapiens [Reaction:R-HSA-9023538] MECP2 binds PTPN1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9023549] PTPN1 gene expression is inhibited by MECP2 - Homo sapiens [Reaction:R-HSA-9006588] MECP2 binds the PTPN4 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9006585] PTPN4 gene expression is stimulated by MECP2 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9021089] MeCP2, a key contributor to neurological disease, activates and represses transcription [LiteratureReference:9021892] Creb1-Mecp2-(m)CpG complex transactivates postnatal murine neuronal glucose transporter isoform 3 expression [LiteratureReference:9017785] MeCP2 deficiency disrupts axonal guidance, fasciculation, and targeting by altering Semaphorin 3F function [LiteratureReference:9006491] NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2 [LiteratureReference:9017905] Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor [LiteratureReference:9017945] Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells [LiteratureReference:9023536] PTP1B inhibition suggests a therapeutic strategy for Rett syndrome [LiteratureReference:9020521] Activity-dependent NR2B expression is mediated by MeCP2-dependent epigenetic regulation [LiteratureReference:9011208] Methyl-CpG Binding Protein 2 (Mecp2) Regulates Sensory Function Through Sema5b and Robo2 [LiteratureReference:9006006] Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice [LiteratureReference:9023137] Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway [LiteratureReference:9022718] Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome [LiteratureReference:8986955] Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome [LiteratureReference:9022360] The Rett syndrome protein MeCP2 regulates synaptic scaling [LiteratureReference:9017942] Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome [LiteratureReference:9022719] Mecp2-null mice provide new neuronal targets for Rett syndrome [LiteratureReference:9006581] Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MECP2 regulates neuronal receptors and channels
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608119] Krishnaraj, Rahul, 2018-08-07 [InstanceEdit:9608114] Christodoulou, John, 2018-08-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9022699
summation	[Summation:9023905] Receptors directly transcriptionally regulated by MECP2 incl...

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[Pathway:R-HSA-8986944] Transcriptional Regulation by MECP2

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