Reactome | G-proteins dissociate from plasma-membrane estrogen receptors

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G-proteins dissociate from plasma-membrane estrogen receptors Show undefined attributes

authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
category	dissociation
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9021598] Rothfels, Karen, 2017-09-18
dbId	9021600
displayName	G-proteins dissociate from plasma-membrane estrogen receptors
eventOf	[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9021596] Membrane estrogen receptors bind SRC - Homo sapiens
input	[Complex:R-HSA-9021595] ESTG:ESRs:STRN:heterotrimeric G(i) protein [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9021569] Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i) [LiteratureReference:9632114] PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells [LiteratureReference:9632116] Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	G-proteins dissociate from plasma-membrane estrogen receptors
orthologousEvent	[Reaction:R-GGA-9021600] G-proteins dissociate from plasma-membrane estrogen receptors - Gallus gallus [Reaction:R-BTA-9021600] G-proteins dissociate from plasma-membrane estrogen receptors - Bos taurus [Reaction:R-CFA-9021600] G-proteins dissociate from plasma-membrane estrogen receptors - Canis familiaris [Reaction:R-MMU-9021600] G-proteins dissociate from plasma-membrane estrogen receptors - Mus musculus
output	[Complex:R-HSA-9027648] ESRs:STRN:ESTG [cytosol] [Complex:R-HSA-392164] G-protein alpha (i):GDP [plasma membrane] [Complex:R-HSA-167434] G-protein beta-gamma complex [plasma membrane]
precedingEvent	[Reaction:R-HSA-9021601] Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19 [InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24 [InstanceEdit:9645002] Marino, Maria, 2019-04-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9021600
summation	[Summation:9021597] Estrogen-stimulation promotes dissociation of the G protein ...

Referrals

(hasEvent)	[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling
(precedingEvent)	[Reaction:R-HSA-9021596] Membrane estrogen receptors bind SRC

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