Reactome | Membrane estrogen receptors bind SRC

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Membrane estrogen receptors bind SRC Show undefined attributes

authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9021598] Rothfels, Karen, 2017-09-18
dbId	9021596
displayName	Membrane estrogen receptors bind SRC
eventOf	[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9021609] ESR-associated SRC autophosphorylates - Homo sapiens
input	[Complex:R-HSA-9027648] ESRs:STRN:ESTG [cytosol] [EntityWithAccessionedSequence:R-HSA-8876922] MyrG-SRC [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9632155] Extranuclear steroid receptors: nature and actions [LiteratureReference:9632169] Roles for oestrogen receptor ? in adult brain function [LiteratureReference:9632158] Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer [LiteratureReference:9632165] Nongenomic actions of steroid hormones [LiteratureReference:9632114] PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells [LiteratureReference:9644981] Distinct nongenomic signal transduction pathways controlled by 17beta-estradiol regulate DNA synthesis and cyclin D(1) gene transcription in HepG2 cells [LiteratureReference:9644980] Biphasic estradiol-induced AKT phosphorylation is modulated by PTEN via MAP kinase in HepG2 cells [LiteratureReference:9021563] Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen [LiteratureReference:9021572] Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells [LiteratureReference:9021578] Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase [LiteratureReference:9021556] Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation [LiteratureReference:9021564] Rapid, estrogen receptor-mediated signaling: why is the endothelium so special? [LiteratureReference:9632160] Minireview: Recent advances in extranuclear steroid receptor actions [LiteratureReference:9632146] Cracking the estrogen receptor's posttranslational code in breast tumors [LiteratureReference:9021569] Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i) [LiteratureReference:9007401] Rapid steroid hormone actions via membrane receptors [LiteratureReference:9632116] Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells [LiteratureReference:9632772] Cell proliferation regulated by estradiol receptor: Therapeutic implications
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Membrane estrogen receptors bind SRC
orthologousEvent	[Reaction:R-GGA-9021596] Membrane estrogen receptors bind SRC - Gallus gallus [Reaction:R-XTR-9021596] Membrane estrogen receptors bind SRC - Xenopus tropicalis [Reaction:R-DRE-9021596] Membrane estrogen receptors bind SRC - Danio rerio [Reaction:R-SSC-9021596] Membrane estrogen receptors bind SRC - Sus scrofa [Reaction:R-BTA-9021596] Membrane estrogen receptors bind SRC - Bos taurus [Reaction:R-CFA-9021596] Membrane estrogen receptors bind SRC - Canis familiaris [Reaction:R-RNO-9021596] Membrane estrogen receptors bind SRC - Rattus norvegicus [Reaction:R-MMU-9021596] Membrane estrogen receptors bind SRC - Mus musculus
output	[Complex:R-HSA-9021587] ESRs:STRN:ESTG:MyrG-SRC [plasma membrane]
precedingEvent	[Reaction:R-HSA-9021600] G-proteins dissociate from plasma-membrane estrogen receptors - Homo sapiens [BlackBoxEvent:R-HSA-9027670] ESTG binding induces ESR depalmitoylation - Homo sapiens
regulatedBy	[PositiveRegulation:9021612] Positive regulation by 'G-protein beta-gamma complex [plasma membrane]' [PositiveRegulation:9021614] Positive regulation by 'G-protein alpha (i):GDP [plasma membrane]'
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19 [InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24 [InstanceEdit:9645002] Marino, Maria, 2019-04-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9021596
summation	[Summation:9021599] Rapid signaling downstream of estrogen stimulation activates...
updateTrackers	[UpdateTracker:9777666] Update Tracker - [Reaction:9021596] Membrane estrogen receptors bind SRC - v69:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777666] Update Tracker - [Reaction:9021596] Membrane estrogen receptors bind SRC - v69:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling
(precedingEvent)	[Reaction:R-HSA-9021609] ESR-associated SRC autophosphorylates

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