Reactome | ESTG binding induces ESR depalmitoylation

Schema > BlackBoxEvent > Entries

ESTG binding induces ESR depalmitoylation Show undefined attributes

authored	[InstanceEdit:9027667] Rothfels, Karen, 2017-11-03
catalystActivity	[CatalystActivity:9027668] palmitoyl hydrolase activity of unknown palmitoyl-(protein) hydrolase [cytosol]
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9027669] Rothfels, Karen, 2017-11-03
dbId	9027670
displayName	ESTG binding induces ESR depalmitoylation
eventOf	[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9021601] Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG - Homo sapiens [Reaction:R-HSA-9021596] Membrane estrogen receptors bind SRC - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-9021165] PalmS-ESRs:STRN:ESTG [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9027654] Membrane association of estrogen receptor alpha and beta influences 17beta-estradiol-mediated cancer cell proliferation [LiteratureReference:9027660] Palmitoylation regulates 17?-estradiol-induced estrogen receptor-? degradation and transcriptional activity [LiteratureReference:9027656] Integration of the extranuclear and nuclear actions of estrogen [LiteratureReference:9022229] Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ESTG binding induces ESR depalmitoylation
output	[Complex:R-HSA-9027648] ESRs:STRN:ESTG [cytosol] [SimpleEntity:R-ALL-8848337] PALM(-) [cytosol]
precedingEvent	[Reaction:R-HSA-9633044] ESR binds STRN - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19 [InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24 [InstanceEdit:9645002] Marino, Maria, 2019-04-24
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9027670
summation	[Summation:9027658] Palmitoylation of the estrogen receptor is dynamic. Binding ...

Referrals

(hasEvent)	[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling
(precedingEvent)	[Reaction:R-HSA-9021596] Membrane estrogen receptors bind SRC [Reaction:R-HSA-9021601] Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG

Cite Us!