Reactome | ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA

ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA

Stable Identifier

R-HSA-9020264

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA

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Lipoxygenase 5 (ALOX5) can oxidise 17(S)-hydroxydocosahexaenoic acid (17(S)-HDHA) into two hydroperoxy intermediates in human polymorphonuclear leukocytes (PMNs) (Serhan et al. 2002). The formation of 4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid (4(S)-Hp-17(S)-HDHA) is decribed here.

Literature References

PubMed ID	Title	Journal	Year
12391014	Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals Gronert, K, Serhan, CN, Devchand, PR, Colgan, SP, Hong, S, Mirick, G, Moussignac, RL	J. Exp. Med.	2002