Reactome | ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE

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ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE Show undefined attributes

authored	[InstanceEdit:9018893] Jassal, Bijay, 2017-09-05
catalystActivity	[CatalystActivity:9020578] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9018893] Jassal, Bijay, 2017-09-05
crossReference	[DatabaseIdentifier:12667877] RHEA:50205 [DatabaseIdentifier:9916395] RHEA:50205
dbId	9018858
displayName	ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE
edited	[InstanceEdit:9018893] Jassal, Bijay, 2017-09-05
eventOf	[Pathway:R-HSA-9018896] Biosynthesis of E-series 18(S)-resolvins - Homo sapiens
followingEvent	[Reaction:R-HSA-9018867] 5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2 - Homo sapiens [Reaction:R-HSA-9018859] ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE - Homo sapiens
input	[SimpleEntity:R-ALL-9020474] 18(S)-HEPE [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9020605] Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis [LiteratureReference:9023641] Resolvin E2 formation and impact in inflammation resolution
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate
orthologousEvent	[Reaction:R-DDI-9018858] ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE - Dictyostelium discoideum [Reaction:R-GGA-9018858] ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE - Gallus gallus [Reaction:R-XTR-9018858] ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE - Xenopus tropicalis [Reaction:R-DRE-9018858] ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE - Danio rerio [Reaction:R-SSC-9018858] ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE - Sus scrofa [Reaction:R-BTA-9018858] ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE - Bos taurus [Reaction:R-CFA-9018858] ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE - Canis familiaris [Reaction:R-RNO-9018858] ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE - Rattus norvegicus [Reaction:R-MMU-9018858] ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE - Mus musculus
output	[SimpleEntity:R-ALL-9020602] 5(S)-Hp-18(S)-HEPE [cytosol]
precedingEvent	[Reaction:R-HSA-9018868] GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9018858
summation	[Summation:9020580] Unlike resolvin E3, which is biosynthesised in eosinophils o...

Referrals

(precedingEvent)	[Reaction:R-HSA-9018867] 5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2 [Reaction:R-HSA-9018859] ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE
(hasEvent)	[Pathway:R-HSA-9018896] Biosynthesis of E-series 18(S)-resolvins

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