ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE

Stable Identifier
R-HSA-9018858
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Unlike resolvin E3, which is biosynthesised in eosinophils or resident macrophages via the 15-lipoxygenase (ALOX15) pathway, resolvins E1 and E2 are biosynthesised by neutrophils via the 5-lipoxygenase pathway. In neutrophils, ALOX5 oxidises 18(S)-hydroxyeicosapentaenoic acid (18(S)-HEPE) to 5(S)-hydroperoxy-18(S)-hydroxyeicosapentaenoic acid (5(S)-Hp-18(S)-HEPE) (Tjonahen et al. 2006, Oh et al. 2012).

Literature References
PubMed ID Title Journal Year
22450811 Resolvin E2 formation and impact in inflammation resolution

Oh, SF, Dona, M, Fredman, G, Krishnamoorthy, S, Irimia, D, Serhan, CN

J. Immunol. 2012
17114001 Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis

Tjonahen, E, Oh, SF, Siegelman, J, Elangovan, S, Percarpio, KB, Hong, S, Arita, M, Serhan, CN

Chem. Biol. 2006
Participants
Participates
Catalyst Activity

arachidonate 5-lipoxygenase activity of ALOX5 [cytosol]

Orthologous Events
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Rhea
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