Reactome | RHOU auto-activates

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RHOU auto-activates Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
catalystActivity	[CatalystActivity:9693872] guanyl-nucleotide exchange factor activity of RHOU:GDP [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9018764] Orlic-Milacic, Marija, 2017-09-05
dbId	9018768
displayName	RHOU auto-activates
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9727277] Orlic-Milacic, Marija, 2021-04-15
eventOf	[Pathway:R-HSA-9013420] RHOU GTPase cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-9018766] RHOU binds effectors at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-9019557] RHOU:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9035998] Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase [LiteratureReference:9693867] Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	RHOU auto-activates
orthologousEvent	[Reaction:R-SCE-9018768] RHOU auto-activates - Saccharomyces cerevisiae [Reaction:R-SPO-9018768] RHOU auto-activates - Schizosaccharomyces pombe [Reaction:R-CEL-9018768] RHOU auto-activates - Caenorhabditis elegans [Reaction:R-DME-9018768] RHOU auto-activates - Drosophila melanogaster [Reaction:R-GGA-9018768] RHOU auto-activates - Gallus gallus [Reaction:R-DRE-9018768] RHOU auto-activates - Danio rerio [Reaction:R-SSC-9018768] RHOU auto-activates - Sus scrofa [Reaction:R-BTA-9018768] RHOU auto-activates - Bos taurus [Reaction:R-CFA-9018768] RHOU auto-activates - Canis familiaris [Reaction:R-RNO-9018768] RHOU auto-activates - Rattus norvegicus [Reaction:R-MMU-9018768] RHOU auto-activates - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-9019560] RHOU:GTP [plasma membrane]
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05 [InstanceEdit:9726808] Shepelev, Mikhail V, 2021-03-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9018768
summation	[Summation:9693869] RHOU is an atypical RHO GTPase with a high intrinsic guanine...
updateTrackers	[UpdateTracker:9776203] Update Tracker - [Reaction:9018768] RHOU auto-activates - v77:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776203] Update Tracker - [Reaction:9018768] RHOU auto-activates - v77:[modifyText]
(hasEvent)	[Pathway:R-HSA-9013420] RHOU GTPase cycle
(precedingEvent)	[Reaction:R-HSA-9018766] RHOU binds effectors at the plasma membrane