RHOU auto-activates

Stable Identifier
R-HSA-9018768
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RHOU is an atypical RHO GTPase with a high intrinsic guanine nucleotide exchange activity. Guanine nucleotide exchange factors (GEFs) are not needed for RHOU activation (Shutes et al. 2004, Saras et al. 2004).

Literature References
PubMed ID Title Journal Year
15556869 Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase

Shutes, A, Berzat, AC, Cox, AD, Der, CJ

Curr. Biol. 2004
15350535 Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects

Saras, J, Wollberg, P, Aspenström, P

Exp. Cell Res. 2004
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of RHOU:GDP [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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