Reactome | RHOU auto-activates

RHOU auto-activates

Stable Identifier

R-HSA-9018768

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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RHOU is an atypical RHO GTPase with a high intrinsic guanine nucleotide exchange activity. Guanine nucleotide exchange factors (GEFs) are not needed for RHOU activation (Shutes et al. 2004, Saras et al. 2004). While some GTPase activator proteins (GAPs) have been reported to interact with RHOU (Bagci et al. 2020), they have not been shown to act on RHOU. Instead, GAPs may serve as RHOU effectors that enable its cross talk with other RHO GTPases (reviewed in Hodge and Ridley 2020). RHOU was shown to possess GTPase activity (Shutes et al. 2004), but the functional importance of GTP hydrolysis in the context of high intrinsic GEF activity and no known GAPs has not been elucidated.

Literature References

PubMed ID	Title	Journal	Year
15350535	Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects Saras, J, Wollberg, P, Aspenström, P	Exp. Cell Res.	2004
15556869	Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase Shutes, A, Berzat, AC, Cox, AD, Der, CJ	Curr. Biol.	2004