Reactome | NOTCH3 binds activated EGFR

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NOTCH3 binds activated EGFR Show undefined attributes

authored	[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9018574] Orlic-Milacic, Marija, 2017-09-01
dbId	9018573
displayName	NOTCH3 binds activated EGFR
edited	[InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
eventOf	[Pathway:R-HSA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus - Homo sapiens
followingEvent	[Reaction:R-HSA-9018572] EGFR phosphorylates NOTCH3 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24614] negative regulation of Notch signaling pathway
input	[Complex:R-HSA-179882] EGF:p-6Y-EGFR dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-157647] NICD3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9018571] EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	NOTCH3 binds activated EGFR
orthologousEvent	[Reaction:R-MMU-9018573] NOTCH3 binds activated EGFR - Mus musculus [Reaction:R-GGA-9018573] NOTCH3 binds activated EGFR - Gallus gallus [Reaction:R-XTR-9018573] NOTCH3 binds activated EGFR - Xenopus tropicalis [Reaction:R-RNO-9018573] NOTCH3 binds activated EGFR - Rattus norvegicus
output	[Complex:R-HSA-9018569] EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-177934] EGFR autophosphorylation - Homo sapiens [Reaction:R-HSA-9013361] NEXT3 is cleaved to produce NICD3 - Homo sapiens
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9027525] Haw, Robin, 2017-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9018573
summation	[Summation:9018587] The intracellular domain of NOTCH3 (NICD3) co-immunoprecipit...

Referrals

(hasEvent)	[Pathway:R-HSA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus
(precedingEvent)	[Reaction:R-HSA-9018572] EGFR phosphorylates NOTCH3

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