NOTCH3 binds activated EGFR

Stable Identifier
R-HSA-9018573
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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NOTCH3 binds activated EGFR
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The intracellular domain of NOTCH3 (NICD3) co-immunoprecipitates with ligand activated, autophosphorylated EGFR. Binding of NOTCH3 to EGFR is inhibited by erlotinib treatment, which prevents EGFR activation (Arasada et al. 2014).

Literature References
PubMed ID Title Journal Year
25125655 EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling

Huppert, SS, Carbone, DP, Arasada, RR, Rahman, MA, Amann, JM

Cancer Res. 2014
Participants
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Output
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as an event of
Event Information
Go Biological Process
negative regulation of Notch signaling pathway (0045746)
Orthologous Events
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NOTCH3 binds activated EGFR (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-09-01)
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