Reactome | Negative regulation by 'factor Xa:Factor Xa inhibitors [plasma membrane]'

Schema > NegativeRegulation > Entries

created	[InstanceEdit:9015054] Jassal, Bijay, 2017-08-08
dbId	9015052
displayName	Negative regulation by 'factor Xa:Factor Xa inhibitors [plasma membrane]'
modified	[InstanceEdit:9733355] Wu, Guanming, 2021-06-04
regulatedEntity	[Reaction:R-HSA-140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - Homo sapiens
regulator	[Complex:R-HSA-9015108] factor Xa:Factor Xa inhibitors [plasma membrane]
schemaClass	NegativeRegulation
stId	R-HSA-9015052

(regulation)	[RegulationReference:9735230] Negative regulation by 'factor Xa:Factor Xa inhibitors [plasma membrane]' Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor
(regulatedBy)	[Reaction:R-HSA-140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)

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