PXLP-K56-SRR dimer isomerises L-Ser to D-Ser

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R-HSA-9014766
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Reaction [transition]
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Homo sapiens
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N-methyl D-aspartate (NMDA) receptors play a key role in excitatory neurotransmission, learning, memory and synaptic plasticity. Their activity is modulated by the agonist glutamate and by the co-agonists D-Serine (D-Ser) and glycine (gly). In human brain, dimeric serine racemase (SRR), a pyridoxal 5'-phosphate-dependent enzyme (Smith et al. 2010), is a bifunctional enzyme mediating mainly the catabolism of L-Serine by alpha,beta-elimination of water to form pyruvate (Foltyn et al. 2005). A small part of L-Serine does not undergo deamination so SRR can also mediate the minor reversible isomerisation of L-Ser to D-Ser (De Miranda et al. 2000, Xia et al. 2004). Thus, D-Ser homeostasis in neurons is modulated by SRR, and therefore indirectly, modulates NMDA receptors. Targeting SRR could find potential in neurodegenerative diseases (Canu et al. 2014). Mg2+ and ATP stimulate SRR (De Miranda et al. 2002).

Literature References
PubMed ID Title Journal Year
11054547 Human serine racemase: moleular cloning, genomic organization and functional analysis

Engelender, S, De Miranda, J, Wolosker, H, Santoro, A

Gene 2000
15193426 Characterization and localization of a human serine racemase

Lu, P, Wei, N, Liu, Y, Chiu, CS, Lawlor, AM, Sur, C, Figueroa, DJ, Xia, M, Connolly, TM, Koblan, KS

Brain Res. Mol. Brain Res. 2004
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serine racemase activity of PXLP-K56-SRR dimer [cytosol]

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