Reactome | HRSP12 deaminates 2-iminobutanoate to 2OBUTA

Schema > Reaction > Entries

HRSP12 deaminates 2-iminobutanoate to 2OBUTA Show undefined attributes

authored	[InstanceEdit:9014640] Jassal, Bijay, 2017-08-02
catalystActivity	[CatalystActivity:9014617] 2-iminobutanoate deaminase activity of HRSP12 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9014640] Jassal, Bijay, 2017-08-02
crossReference	[DatabaseIdentifier:12668012] RHEA:39976 [DatabaseIdentifier:9929609] RHEA:39976
dbId	9014641
displayName	HRSP12 deaminates 2-iminobutanoate to 2OBUTA
edited	[InstanceEdit:9014640] Jassal, Bijay, 2017-08-02
eventOf	[Pathway:R-HSA-8849175] Threonine catabolism - Homo sapiens
input	[SimpleEntity:R-ALL-9929622] 2-iminobutanoate [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9014628] Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions [LiteratureReference:9014629] RidA proteins prevent metabolic damage inflicted by PLP-dependent dehydratases in all domains of life [LiteratureReference:9014624] Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family [LiteratureReference:9034683] Cysteine S-conjugate ?-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents [LiteratureReference:9014639] From microbiology to cancer biology: the Rid protein family prevents cellular damage caused by endogenously generated reactive nitrogen species
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	HRSP12 deaminates 2-iminobutanoate to 2OBUTA 2-iminobutanoate + H2O => 2-oxobutanoate + NH4(+)
orthologousEvent	[Reaction:R-RNO-9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - Rattus norvegicus [Reaction:R-DDI-9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - Dictyostelium discoideum [Reaction:R-CEL-9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - Caenorhabditis elegans [Reaction:R-DME-9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - Drosophila melanogaster [Reaction:R-GGA-9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - Gallus gallus [Reaction:R-XTR-9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - Xenopus tropicalis [Reaction:R-DRE-9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - Danio rerio [Reaction:R-SSC-9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - Sus scrofa [Reaction:R-BTA-9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - Bos taurus [Reaction:R-CFA-9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - Canis familiaris [Reaction:R-MMU-9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - Mus musculus
output	[SimpleEntity:R-ALL-936714] 2OBUTA [cytosol] [SimpleEntity:R-ALL-31633] NH4+ [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9038492] Downs, Diana, 2018-02-28 [InstanceEdit:9038495] Cooper, Arthur, 2018-02-28 [InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9014641
summation	[Summation:9014644] The toxic enamine/imine intermediates generated by pyridoxal...
updateTrackers	[UpdateTracker:9939820] Update Tracker - [Reaction:9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - v92:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9939820] Update Tracker - [Reaction:9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - v92:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-8849175] Threonine catabolism

Cite Us!