Reactome | Threonine catabolism

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Threonine catabolism Show undefined attributes

authored	[InstanceEdit:8849176] Jassal, Bijay, 2015-12-14
created	[InstanceEdit:8849176] Jassal, Bijay, 2015-12-14
dbId	8849175
deleted	[Deleted:9939310] Deletion of instance: 6798345 [Deleted:9939314] Deletion of instance: 6798667
displayName	Threonine catabolism
edited	[InstanceEdit:8849176] Jassal, Bijay, 2015-12-14
eventOf	[Pathway:R-HSA-71291] Metabolism of amino acids and derivatives - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:10163] L-threonine catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9014627] SDS dimers:PXLP convert L-Thr to 2OBUTA - Homo sapiens [Reaction:R-HSA-9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-03-26
literatureReference	[LiteratureReference:9939306] Metabolic homoeostasis of L-threonine in the normally-fed rat. Importance of liver threonine dehydrogenase activity [LiteratureReference:8849179] Catabolism of threonine in mammals by coupling of L-threonine 3-dehydrogenase with 2-amino-3-oxobutyrate-CoA ligase [LiteratureReference:8849181] Threonine dehydrogenase is a minor degradative pathway of threonine catabolism in adult humans [LiteratureReference:6798664] The human L-threonine 3-dehydrogenase gene is an expressed pseudogene [LiteratureReference:6798669] Interaction between L-threonine dehydrogenase and aminoacetone synthetase and mechanism of aminoacetone production
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Threonine catabolism
orthologousEvent	[Pathway:R-RNO-8849175] Threonine catabolism - Rattus norvegicus [Pathway:R-SCE-8849175] Threonine catabolism - Saccharomyces cerevisiae [Pathway:R-DDI-8849175] Threonine catabolism - Dictyostelium discoideum [Pathway:R-CEL-8849175] Threonine catabolism - Caenorhabditis elegans [Pathway:R-DME-8849175] Threonine catabolism - Drosophila melanogaster [Pathway:R-GGA-8849175] Threonine catabolism - Gallus gallus [Pathway:R-XTR-8849175] Threonine catabolism - Xenopus tropicalis [Pathway:R-DRE-8849175] Threonine catabolism - Danio rerio [Pathway:R-SSC-8849175] Threonine catabolism - Sus scrofa [Pathway:R-BTA-8849175] Threonine catabolism - Bos taurus [Pathway:R-CFA-8849175] Threonine catabolism - Canis familiaris [Pathway:R-MMU-8849175] Threonine catabolism - Mus musculus
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11 [InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8849175
summation	[Summation:8849180] In many mammals, threonine can be catabolized either via mit...
updateTrackers	[UpdateTracker:9779720] Update Tracker - [Pathway:8849175] Threonine catabolism - v64:[addHasEvent] [UpdateTracker:9939665] Update Tracker - [Pathway:8849175] Threonine catabolism - v92:[addHasEvent, modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9779720] Update Tracker - [Pathway:8849175] Threonine catabolism - v64:[addHasEvent] [UpdateTracker:9939665] Update Tracker - [Pathway:8849175] Threonine catabolism - v92:[addHasEvent, modifyText, removeLiteratureReference]
(replacementInstances)	[Deleted:9939310] Deletion of instance: 6798345 [Deleted:9939314] Deletion of instance: 6798667
(hasEvent)	[Pathway:R-HSA-71291] Metabolism of amino acids and derivatives

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