Reactome | HRSP12 deaminates 2AA to 2OBUTA

HRSP12 deaminates 2AA to 2OBUTA

Stable Identifier

R-HSA-9014641

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The toxic enamine/imine intermediates generated by pyridoxal 5'-phosphate (PXLP) containing enzymes can cause severe cellular damage if allowed to accumulate (Downs & Ernst 2015). 2-iminobutanoate/2-iminopropanoate deaminase (RIDA aka HRSP12) is a widely conserved protein that prevents 2AA accumulation by facilitating its conversion to the stable metabolite 2-oxobutanoate (2OBUTA aka 2-ketobutyrate) (Cooper et al. 2011, Lambrecht et al. 2012, 2013, Niehaus et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
22094463	Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions Downs, DM, Flynn, JM, Lambrecht, JA	J. Biol. Chem.	2012
23386433	RidA proteins prevent metabolic damage inflicted by PLP-dependent dehydratases in all domains of life Downs, DM, Lambrecht, JA, Schmitz, GE	MBio	2013
25975565	Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family Cooper, AJ, Gerdes, S, Hanson, AD, Downs, DM, ElBadawi-Sidhu, M, Fiehn, O, Zhukov, A, Hodge-Hanson, K, Niehaus, TD	BMC Genomics	2015
20306345	Cysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents Cooper, AJ, Callery, PS, Pinto, JT, Krasnikov, BF, Bruschi, SA, Villar, MT, Niatsetskaya, ZV, Artigues, A	Amino Acids	2011