HRSP12 deaminates 2AA to 2OBUTA

Stable Identifier
R-HSA-9014641
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The toxic enamine/imine intermediates generated by pyridoxal 5'-phosphate (PXLP) containing enzymes can cause severe cellular damage if allowed to accumulate (Downs & Ernst 2015). 2-iminobutanoate/2-iminopropanoate deaminase (RIDA aka HRSP12) is a widely conserved protein that prevents 2AA accumulation by facilitating its conversion to the stable metabolite 2-oxobutanoate (2OBUTA aka 2-ketobutyrate) (Cooper et al. 2011, Lambrecht et al. 2012, 2013, Niehaus et al. 2015).

Literature References
PubMed ID Title Journal Year
23386433 RidA proteins prevent metabolic damage inflicted by PLP-dependent dehydratases in all domains of life

Lambrecht, JA, Schmitz, GE, Downs, DM

MBio 2013
22094463 Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions

Lambrecht, JA, Flynn, JM, Downs, DM

J. Biol. Chem. 2012
25975565 Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family

Niehaus, TD, Gerdes, S, Hodge-Hanson, K, Zhukov, A, Cooper, AJ, ElBadawi-Sidhu, M, Fiehn, O, Downs, DM, Hanson, AD

BMC Genomics 2015
20306345 Cysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents

Cooper, AJ, Krasnikov, BF, Niatsetskaya, ZV, Pinto, JT, Callery, PS, Villar, MT, Artigues, A, Bruschi, SA

Amino Acids 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
deaminase activity of HRSP12 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created