The toxic enamine/imine intermediates generated by pyridoxal 5'-phosphate (PXLP) containing enzymes can cause severe cellular damage if allowed to accumulate (Downs & Ernst 2015). 2-iminobutanoate/2-iminopropanoate deaminase (RIDA aka HRSP12) is a widely conserved protein that prevents 2AA accumulation by facilitating its conversion to the stable metabolite 2-oxobutanoate (2OBUTA aka 2-ketobutyrate) (Cooper et al. 2011, Lambrecht et al. 2012, 2013, Niehaus et al. 2015).
Downs, DM, Flynn, JM, Lambrecht, JA
Downs, DM, Lambrecht, JA, Schmitz, GE
Cooper, AJ, Gerdes, S, Hanson, AD, Downs, DM, ElBadawi-Sidhu, M, Fiehn, O, Zhukov, A, Hodge-Hanson, K, Niehaus, TD
Cooper, AJ, Callery, PS, Pinto, JT, Krasnikov, BF, Bruschi, SA, Villar, MT, Niatsetskaya, ZV, Artigues, A
deaminase activity of HRSP12 [cytosol]
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