The toxic enamine/imine intermediates generated by pyridoxal 5'-phosphate (PXLP) containing enzymes can cause severe cellular damage if allowed to accumulate (Downs & Ernst 2015). 2-iminobutanoate/2-iminopropanoate deaminase (RIDA aka HRSP12) is a widely conserved protein that prevents 2AA accumulation by facilitating its conversion to the stable metabolite 2-oxobutanoate (2OBUTA aka 2-ketobutyrate) (Cooper et al. 2011, Lambrecht et al. 2012, 2013, Niehaus et al. 2015).
Lambrecht, JA, Schmitz, GE, Downs, DM
Lambrecht, JA, Flynn, JM, Downs, DM
Niehaus, TD, Gerdes, S, Hodge-Hanson, K, Zhukov, A, Cooper, AJ, ElBadawi-Sidhu, M, Fiehn, O, Downs, DM, Hanson, AD
Cooper, AJ, Krasnikov, BF, Niatsetskaya, ZV, Pinto, JT, Callery, PS, Villar, MT, Artigues, A, Bruschi, SA
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