RHOQ GTPase cycle

Stable Identifier
Homo sapiens
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This pathway catalogues RHOQ (also known as TC10) guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), and RHOQ effectors. No GDP dissociation inhibitors (GDIs) have been shown to interact with RHOQ. Two GDIs, ARHGDIA (Michaelson et al. 2001; Murphy et al. 2001) and ARHGDIB (Zhang et al. 2009), were specifically shown not to interact with RHOQ. RHOQ, together with RHOJ (TCL), belongs to the CDC42 subfamily of RHO GTPases, with the three family members sharing 70-85% of homology (Donnelly et al. 2014; Shi et al. 2016). RHOQ is highly activated on exocytosing vesicles and recycling endosomes. RHOQ GTPase activity is necessary for fusion of vesicles with the plasma membrane (Donnelly et al. 2014). RHOQ is required for insulin-stimulated glucose uptake (Kanzaki and Pessin 2003; Saltiel and Pessin 2003) and is involved in insulin signaling in adipocytes (Satoh 2014). RHOQ is involved in neurite outgrowth and regulates membrane addition during axon formation (Gonzalez‐Billault et al. 2012).

Literature References
PubMed ID Title Journal Year
22605667 The role of small GTPases in neuronal morphogenesis and polarity

González-Billault, C, Muñoz-Llancao, P, Henriquez, DR, Wojnacki, J, Conde, C, Caceres, A

Cytoskeleton (Hoboken) 2012
27556037 The Role of RhoJ in Endothelial Cell Biology and Tumor Pathology

Shi, TT, Li, G, Xiao, HT

Biomed Res Int 2016
11306516 Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways

Murphy, GA, Jillian, SA, Michaelson, D, Philips, MR, D'Eustachio, P, Rush, MG

Cell Growth Differ. 2001
11149925 Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

Michaelson, D, Silletti, J, Murphy, GA, D'Eustachio, P, Rush, MG, Philips, MR

J. Cell Biol. 2001
24613967 Rho GTPases in insulin-stimulated glucose uptake

Satoh, T

Small GTPases 2014
25482645 Rho GTPase isoforms in cell motility: Don't fret, we have FRET

Donnelly, SK, Bravo-Cordero, JJ, Hodgson, L

Cell Adh Migr 2014
19269969 Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling

Zhang, Y, Rivera Rosado, LA, Moon, SY, Zhang, B

J. Biol. Chem. 2009
12867054 Insulin signaling: GLUT4 vesicles exit via the exocyst

Kanzaki, M, Pessin, JE

Curr. Biol. 2003
14617354 Insulin signaling in microdomains of the plasma membrane

Saltiel, AR, Pessin, JE

Traffic 2003
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