Reactome | RHOB GEFs activate RHOB

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RHOB GEFs activate RHOB Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
catalystActivity	[CatalystActivity:9013033] guanyl-nucleotide exchange factor activity of RHOB GEFs [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9013025] Orlic-Milacic, Marija, 2017-07-21
dbId	9013023
deleted	[Deleted:9768327] Deletion of instance: 194913
displayName	RHOB GEFs activate RHOB
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
eventOf	[Pathway:R-HSA-9013026] RHOB GTPase cycle - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9690494] RHOB translocates to the endosome membrane - Homo sapiens [Reaction:R-HSA-9013024] RHOB binds effectors at the plasma membrane - Homo sapiens [Reaction:R-HSA-9013022] RHOB GAPs stimulate RHOB GTPase activity - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-8985690] RHOB:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9644217] Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins [LiteratureReference:8980798] Direct involvement of the small GTP-binding protein Rho in lbc oncogene function [LiteratureReference:8980771] Divergence of Rho residue 43 impacts GEF activity [LiteratureReference:8980821] Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture [LiteratureReference:8980715] GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor [LiteratureReference:8980712] Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4 [LiteratureReference:8980733] Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG) [LiteratureReference:5229003] Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2 [LiteratureReference:8980837] Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5 [LiteratureReference:8980763] XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC [LiteratureReference:9690428] The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage [LiteratureReference:9690433] TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation [LiteratureReference:9679569] SWAP-70 regulates RhoA/RhoB-dependent MHCII surface localization in dendritic cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	RHOB GEFs activate RHOB
orthologousEvent	[Reaction:R-GGA-9013023] RHOB GEFs activate RHOB - Gallus gallus [Reaction:R-XTR-9013023] RHOB GEFs activate RHOB - Xenopus tropicalis [Reaction:R-DRE-9013023] RHOB GEFs activate RHOB - Danio rerio [Reaction:R-SSC-9013023] RHOB GEFs activate RHOB - Sus scrofa [Reaction:R-RNO-9013023] RHOB GEFs activate RHOB - Rattus norvegicus [Reaction:R-MMU-9013023] RHOB GEFs activate RHOB - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-8981459] RHOB:GTP [plasma membrane]
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9013023
summation	[Summation:9690437] The following guanine nucleotide exchange factors (GEFs) wer...

Referrals

(replacementInstances)	[Deleted:9768327] Deletion of instance: 194913
(precedingEvent)	[BlackBoxEvent:R-HSA-9690494] RHOB translocates to the endosome membrane [Reaction:R-HSA-9013024] RHOB binds effectors at the plasma membrane [Reaction:R-HSA-9013022] RHOB GAPs stimulate RHOB GTPase activity
(hasEvent)	[Pathway:R-HSA-9013026] RHOB GTPase cycle

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