Reactome | RHOB binds effectors at the plasma membrane

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RHOB binds effectors at the plasma membrane Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9013025] Orlic-Milacic, Marija, 2017-07-21
dbId	9013024
deleted	[Deleted:9716816] Deletion of instance: 194894
displayName	RHOB binds effectors at the plasma membrane
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
eventOf	[Pathway:R-HSA-9013026] RHOB GTPase cycle - Homo sapiens
input	[CandidateSet:R-HSA-9013052] RHOB effectors (plasma membrane) [cytosol] [Complex:R-HSA-8981459] RHOB:GTP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5627666] The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton [LiteratureReference:5623615] Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB [LiteratureReference:5625892] A novel partner for the GTP-bound forms of rho and rac [LiteratureReference:5625916] Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron [LiteratureReference:9679344] Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms [LiteratureReference:5666071] Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets [LiteratureReference:5666179] Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain [LiteratureReference:5665745] Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC [LiteratureReference:9694071] Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	RHOB binds effectors at the plasma membrane
orthologousEvent	[Reaction:R-GGA-9013024] RHOB binds effectors at the plasma membrane - Gallus gallus [Reaction:R-XTR-9013024] RHOB binds effectors at the plasma membrane - Xenopus tropicalis [Reaction:R-DRE-9013024] RHOB binds effectors at the plasma membrane - Danio rerio [Reaction:R-SSC-9013024] RHOB binds effectors at the plasma membrane - Sus scrofa [Reaction:R-RNO-9013024] RHOB binds effectors at the plasma membrane - Rattus norvegicus [Reaction:R-MMU-9013024] RHOB binds effectors at the plasma membrane - Mus musculus
output	[Complex:R-HSA-9013053] RHOB:GTP:cytosolic RHOB effectors [plasma membrane]
precedingEvent	[Reaction:R-HSA-9013023] RHOB GEFs activate RHOB - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9013024
summation	[Summation:9690070] In its GTP bound active form, plasma membrane associated RHO...

Referrals

(replacementInstances)	[Deleted:9716816] Deletion of instance: 194894
(hasEvent)	[Pathway:R-HSA-9013026] RHOB GTPase cycle

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