RHOB GEFs activate RHOB

Stable Identifier
R-HSA-9013023
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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The following guanine nucleotide exchange factors (GEFs) were shown to bind RHOB and catalyze GDP to GTP exchange on RHOB, resulting in formation of the active RHOB:GTP complex:
AKAP13 (Zheng et al. 1995)
ARHGEF1 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF2 (Kamon et al. 2006)
ARHGEF3 (Arthur et al. 2002; Sloan et al. 2012)
ARHGEF5 (Wang et al. 2009)
ARHGEF10 (Mohl et al. 2006)
ARHGEF10L (Winkler et al. 2005)
ARHGEF11 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF12 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF17 (Mitin et al. 2012)
ARHGEF25 (Sloan et al. 2012)
ARHGEF28 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ECT2 (Srougi and Burridge 2011)
MCF2 (Sloan et al. 2012; Jaiswal et al. 2013)
MCF2L (Sloan et al. 2012; Jaiswal et al. 2013)
NET1 (Srougi and Burridge 2011)
PREX1 (Jaiswal et al. 2013)
VAV2 (Sloan et al. 2012; Schuebel et al. 1998; Jaiswal et al. 2013)

The following GEFs do not act on RHOB:
ARHGEF4 (Jaiswal et al. 2013)
ARHGEF9 (Jaiswal et al. 2013)
DNMBP (Jaiswal et al. 2013)
ITSN1 (Jaiswal et al. 2013)
SWAP70 (Ocana-Morgner et al. 2009)
TIAM1 (Jaiswal et al. 2013)

Literature References
PubMed ID Title Journal Year
7721814 Direct involvement of the small GTP-binding protein Rho in lbc oncogene function

Zheng, Y, Olson, MF, Hall, A, Cerione, RA, Toksoz, D

J. Biol. Chem. 1995
16896804 Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture

Mohl, M, Winkler, S, Wieland, T, Lutz, S

Naunyn Schmiedebergs Arch. Pharmacol. 2006
21454492 Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG)

Jaiswal, M, Gremer, L, Dvorsky, R, Haeusler, LC, Cirstea, IC, Uhlenbrock, K, Ahmadian, MR

J. Biol. Chem. 2011
16917499 TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation

Kamon, H, Kawabe, T, Kitamura, H, Lee, J, Kamimura, D, Kaisho, T, Akira, S, Iwamatsu, A, Koga, H, Murakami, M, Hirano, T

EMBO J. 2006
12221096 XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

Arthur, WT, Ellerbroek, SM, Der, CJ, Burridge, K, Wennerberg, K

J. Biol. Chem. 2002
21373644 The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage

Srougi, MC, Burridge, K

PLoS ONE 2011
19713215 Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5

Wang, Z, Kumamoto, Y, Wang, P, Gan, X, Lehmann, D, Smrcka, AV, Cohn, L, Iwasaki, A, Li, L, Wu, D

J. Biol. Chem. 2009
22673745 Divergence of Rho residue 43 impacts GEF activity

Sloan, CM, Quinn, CV, Peters, JP, Farley, J, Goetzinger, C, Wernli, M, DeMali, KA, Ellerbroek, SM

Small GTPases 2012
23255595 Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins

Jaiswal, M, Dvorsky, R, Ahmadian, MR

J. Biol. Chem. 2013
9822605 Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

Schuebel, KE, Movilla, N, Rosa, JL, Bustelo, XR

EMBO J. 1998
18802007 SWAP-70 regulates RhoA/RhoB-dependent MHCII surface localization in dendritic cells

Ocana-Morgner, C, Wahren, C, Jessberger, R

Blood 2009
16112081 GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor

Winkler, S, Mohl, M, Wieland, T, Lutz, S

Biochem. Biophys. Res. Commun. 2005
22911862 Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4

Mitin, N, Rossman, KL, Der, CJ

PLoS ONE 2012
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of RHOB GEFs [cytosol]

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