Reactome | GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu

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GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu Show undefined attributes

authored	[InstanceEdit:9012600] Jassal, Bijay, 2017-07-17
catalystActivity	[CatalystActivity:9012605] L-cysteine transaminase activity of GOT2 dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9012600] Jassal, Bijay, 2017-07-17
crossReference	[DatabaseIdentifier:12667628] RHEA:17442 [DatabaseIdentifier:9930116] RHEA:17442
dbId	9012597
displayName	GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu
edited	[InstanceEdit:9012600] Jassal, Bijay, 2017-07-17
eventOf	[Pathway:R-HSA-1614558] Degradation of cysteine and homocysteine - Homo sapiens
followingEvent	[Reaction:R-HSA-9013471] MPST transfers sulfur from 3MPYR to HCN to form HSCN - Homo sapiens [Reaction:R-HSA-9012721] MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR - Homo sapiens [Reaction:R-HSA-9034756] MPST transfers sulfur atom from 3MPYR to form CysS248-MPST - Homo sapiens
inferredFrom	[Reaction:R-RNO-9012709] Got2:PLXP dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu - Rattus norvegicus
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-379721] L-Cys [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9012613] Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells
maxDepth	1
modified	[InstanceEdit:9930119] D'Eustachio, Peter, 2024-12-02
name	GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu 2-oxoglutarate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-glutamate
output	[SimpleEntity:R-ALL-9012592] 3MPYR [mitochondrial matrix] [SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix]
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9034788] Kimura, Hideo, 2018-01-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9012597
summation	[Summation:9012595] Hydrogen sulfide (H2S) produced endogenously has been establ...

Referrals

(hasEvent)	[Pathway:R-HSA-1614558] Degradation of cysteine and homocysteine
(precedingEvent)	[Reaction:R-HSA-9013471] MPST transfers sulfur from 3MPYR to HCN to form HSCN [Reaction:R-HSA-9012721] MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR [Reaction:R-HSA-9034756] MPST transfers sulfur atom from 3MPYR to form CysS248-MPST
(inferredTo)	[Reaction:R-RNO-9012709] Got2:PLXP dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu

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