Reactome | Estrogen-responsive GREB1 gene transcription

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Estrogen-responsive GREB1 gene transcription Show undefined attributes

authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9011953] Rothfels, Karen, 2017-07-06
dbId	9011950
displayName	Estrogen-responsive GREB1 gene transcription
edited	[InstanceEdit:9028899] Rothfels, Karen, 2017-11-13
eventOf	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression - Homo sapiens
followingEvent	[Reaction:R-HSA-9038052] GREB1 binds ESR1:ESTG and co-activators - Homo sapiens [Reaction:R-HSA-9011958] miR-26A and B bind to the 3'UTR of the GREB1 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-9011961] GREB1 translation is negatively regulated by miR-26A and B - Homo sapiens [BlackBoxEvent:R-HSA-9012196] KPNA2 translation is negatively regulated by miR-26A and B - Homo sapiens [BlackBoxEvent:R-HSA-9012186] CHD1 translation is negatively regulated by miR-26A and B - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9011672] GREB1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9011811] PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer [LiteratureReference:9011795] GREB 1 is a critical regulator of hormone dependent breast cancer growth [LiteratureReference:9011808] Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells [LiteratureReference:9011656] Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development [LiteratureReference:9011766] A functional interplay between ZNF217 and estrogen receptor alpha exists in luminal breast cancers [LiteratureReference:9011783] Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells [LiteratureReference:9011818] Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences [LiteratureReference:9012158] Novel estrogen receptor-alpha binding sites and estradiol target genes identified by chromatin immunoprecipitation cloning in breast cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Estrogen-responsive GREB1 gene transcription
output	[EntityWithAccessionedSequence:R-HSA-9011854] GREB1 mRNA [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9012000] NR5A2, ZNF217 and NCOA3 bind GREB1 promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-9011951] Positive gene expression regulation by 'GREB1 gene:nucleosome:ESR1:ESTG:ZNF217:NCOA3:NR5A2 [nucleoplasm]'
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9038169] Magnani, Luca, 2018-02-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9011950
summation	[Summation:9012191] GREB1 is transcribed in response to estrogen stimulation in ...

Referrals

(precedingEvent)

[BlackBoxEvent:R-HSA-9011961] GREB1 translation is negatively regulated by miR-26A and B
[BlackBoxEvent:R-HSA-9012196] KPNA2 translation is negatively regulated by miR-26A and B
[Reaction:R-HSA-9038052] GREB1 binds ESR1:ESTG and co-activators
[Reaction:R-HSA-9011958] miR-26A and B bind to the 3'UTR of the GREB1 mRNA
[BlackBoxEvent:R-HSA-9012186] CHD1 translation is negatively regulated by miR-26A and B

(hasEvent)

[Pathway:R-HSA-9018519] Estrogen-dependent gene expression

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