Reactome | TBK1 phosphorylation

Schema > BlackBoxEvent > Entries

TBK1 phosphorylation Show undefined attributes

authored	[InstanceEdit:9023343] Varusai, Thawfeek, 2017-09-27
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9008689] Varusai, Thawfeek, 2017-06-13
dbId	9008684
displayName	TBK1 phosphorylation
edited	[InstanceEdit:9023343] Varusai, Thawfeek, 2017-09-27
eventOf	[Pathway:R-HSA-9008059] Interleukin-37 signaling - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-166267] TBK1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2408424] IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	TBK1 phosphorylation
orthologousEvent	[BlackBoxEvent:R-BTA-9008684] TBK1 phosphorylation - Bos taurus [BlackBoxEvent:R-DME-9008684] TBK1 phosphorylation - Drosophila melanogaster [BlackBoxEvent:R-GGA-9008684] TBK1 phosphorylation - Gallus gallus [BlackBoxEvent:R-XTR-9008684] TBK1 phosphorylation - Xenopus tropicalis [BlackBoxEvent:R-DRE-9008684] TBK1 phosphorylation - Danio rerio [BlackBoxEvent:R-SSC-9008684] TBK1 phosphorylation - Sus scrofa [BlackBoxEvent:R-CFA-9008684] TBK1 phosphorylation - Canis familiaris [BlackBoxEvent:R-RNO-9008684] TBK1 phosphorylation - Rattus norvegicus [BlackBoxEvent:R-MMU-9008684] TBK1 phosphorylation - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-9008705] p-TBK1 [cytosol]
precedingEvent	[Reaction:R-HSA-9008577] IL37:IL18R1 binds SIGIRR - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-9012247] Negative regulation by 'IL18R1:IL37,IL37(?-218):SIGIRR [plasma membrane]'
regulationReference	[RegulationReference:9642536] Negative regulation by 'IL18R1:IL37,IL37(?-218):SIGIRR [plasma membrane]' IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9027502] Carriero, Roberta, 2017-11-02 [InstanceEdit:9027496] Garlanda, Cecilia, 2017-11-02 [InstanceEdit:9027499] Mantovani, Alberto, 2017-11-02
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9008684
summation	[Summation:9008690] Serine/threonine protein kinase TBK1 plays a key role in reg...

Referrals

(hasEvent)

[Pathway:R-HSA-9008059] Interleukin-37 signaling