TBK1 phosphorylation

Stable Identifier
R-HSA-9008684
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Serine/threonine protein kinase TBK1 plays a key role in regulating inflammatory responses. TBK1 activity is regulated by phosphorylation of Ser 172 within the kinase activation loop (Kishore et al. 2002). TBK1 phosphorylation is thought to be an autoactivation event. The IL 37b:IL-18R1:SIGIRR complex can suppress TBK1 activity (Nold Petry et al. 2015, Clark K et al. 2009). This event is set as a black box event instance because the precise mechanism of TBK1 suppression by IL 37b:IL-18R1:SIGIRR complex is uncertain.

Literature References
PubMed ID Title Journal Year
11839743 IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2

Kishore, N, Huynh, QK, Mathialagan, S, Hall, T, Rouw, S, Creely, D, Lange, G, Caroll, J, Reitz, B, Donnelly, A, Boddupalli, H, Combs, RG, Kretzmer, K, Tripp, CS

J. Biol. Chem. 2002
Participants
Participant Of
This event is regulated
Orthologous Events
Authored
Reviewed
Created