IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3

Stable Identifier
R-HSA-9006422
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3
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Binding of the RUNX1:CBFB complex to the interferon gamma (IFNG) gene promoter stimulates IFNG transcription. If FOXP3 is present in the complex with RUNX1, the IFNG gene transcription is inhibited. Suppressed IFNG production is one of the hallmarks of regulatory T cells (Tregs) (Ono et al. 2007).
Literature References
PubMed ID Title Journal Year
17377532 Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Nagamura, Y, Ono, M, Kitabayashi, I, Tsukada, T, Ohkura, N, Sakaguchi, S, Nomura, T, Yaguchi, H, Miyachi, Y

Nature 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
RUNX1:CBFB:FOXP3:IFNG gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXP3 [nucleoplasm]
Positively by
Regulator
RUNX1:CBFB:IFNG gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2017-05-16)
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