Reactome | MECP2 binds the NCoR/SMRT complex

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MECP2 binds the NCoR/SMRT complex Show undefined attributes

authored	[InstanceEdit:9024208] Orlic-Milacic, Marija, 2017-10-02
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8986945] Orlic-Milacic, Marija, 2017-05-05
dbId	8986939
diseaseReaction	[FailedReaction:R-NUL-9005752] MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/Smrt complex - Homo sapiens [FailedReaction:R-HSA-9005585] MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/SMRT complex - Homo sapiens
displayName	MECP2 binds the NCoR/SMRT complex
edited	[InstanceEdit:9615799] Orlic-Milacic, Marija, 2018-08-08
eventOf	[Pathway:R-HSA-9022692] Regulation of MECP2 expression and activity - Homo sapiens
inferredFrom	[Reaction:R-NUL-9005747] MECP2 binds the NCoR/Smrt complex - Homo sapiens
input	[CandidateSet:R-HSA-9005549] MECP2 [nucleoplasm] [DefinedSet:R-HSA-9005706] NCoR/SMRT complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8986952] Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR [LiteratureReference:9005556] Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MECP2 binds the NCoR/SMRT complex
output	[Complex:R-HSA-9005564] MECP2:NCoR/SMRT complex [nucleoplasm]
regulatedBy	[NegativeRegulation:9005545] Negative regulation by 'Active PRKACA,CaMK IV [nucleoplasm]'
regulationReference	[RegulationReference:9641774] Negative regulation by 'Active PRKACA,CaMK IV [nucleoplasm]' Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608119] Krishnaraj, Rahul, 2018-08-07 [InstanceEdit:9608114] Christodoulou, John, 2018-08-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8986939
summation	[Summation:8986941] MECP2 binds the nuclear receptor co-repressor complex (NCoR/...

Referrals

(normalReaction)	[FailedReaction:R-NUL-9005752] MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/Smrt complex [FailedReaction:R-HSA-9005585] MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/SMRT complex
(hasEvent)	[Pathway:R-HSA-9022692] Regulation of MECP2 expression and activity
(inferredTo)	[Reaction:R-NUL-9005747] MECP2 binds the NCoR/Smrt complex