MECP2 binds the NCoR/SMRT complex

Stable Identifier
R-HSA-8986939
Type
Reaction [binding]
Species
Homo sapiens
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MECP2 binds the nuclear receptor co-repressor complex (NCoR/SMRT). This interaction is inhibited by MECP2 phosphorylation at threonine residue T308. The following NCoR/SMRT complex components were co-immunoprecipitated with MECP2: NCOR1, NCOR2, HDAC3, TBL1 (TBL1X), TBLR1 (TBL1XR1) and GPS2 (Lyst et al. 2013, Ebert et al. 2013). Direct interaction was confirmed between the transcriptional repressor domain of MECP2 and NCOR1, NCOR2, TBL1X and TBLR1 (Lyst et al. 2013). NCoR/SMRT complex consists of either NCOR1 (NCoR) or NCOR2 (SMRT), GPS2, HDAC3 and tetramers of either TBL1X or TBL1XR1 (Oberoi et al. 2011, reviewed by Watson et al. 2012).

Literature References
PubMed ID Title Journal Year
23770587 Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR

Ebert, DH, Gabel, HW, Robinson, ND, Kastan, NR, Hu, LS, Cohen, S, Navarro, AJ, Lyst, MJ, Ekiert, R, Bird, AP, Greenberg, ME

Nature 2013
23770565 Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

Lyst, MJ, Ekiert, R, Ebert, DH, Merusi, C, Nowak, J, Selfridge, J, Guy, J, Kastan, NR, Robinson, ND, de Lima Alves, F, Rappsilber, J, Greenberg, ME, Bird, A

Nat. Neurosci. 2013
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