USP33 deubiquitinates ROBO1

Stable Identifier
Reaction [transition]
Homo sapiens
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The ubiquitin protease USP33 deubiquitinates ROBO1, thus stabilizing it and increasing the concentration of ROBO1 at the plasma membrane (Yuasa-Kawada et al. 2009, Huang et al. 2015). USP33 is frequently downregulated in colorectal cancer, which is associated with lymph node metastasis and poor survival (Huang et al. 2015). USP33 is required for SLIT-ROBO1-mediated inhibition of breast cancer cell migration (Yuasa-Kawada et al. 2009). Ubiquitin ligases that ubiquitinate ROBO1 are not known.

Literature References
PubMed ID Title Journal Year
19706539 Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration

Rao, Y, Kinoshita-Kawada, M, Wu, JY, Yuasa-Kawada, J

Proc. Natl. Acad. Sci. U.S.A. 2009
25242263 USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration

Zhu, L, Wen, P, Liu, J, Kong, R, Wu, JY, Chen, X, Hua, D, Zhang, B, Bian, Z, Huang, Z, Cheng, H, Du, X, Fushimi, K, Zhang, Z, Chen, M, Quan, C

Int. J. Cancer 2015
Catalyst Activity

cysteine-type deubiquitinase activity of USP33 [cytosol]

Orthologous Events
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