COL1A1 gene expression is stimulated by RUNX2 and RB1

Stable Identifier
R-HSA-8985644
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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COL1A1 gene expression is stimulated by RUNX2 and RB1
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Based on mouse studies, binding of the RUNX2:RB1 complex to RUNX2-response elements in the promoter of the COL1A1 gene, encoding Collagen alpha-1(I) chain, stimulates COL1A1 transcription (Kern et al. 2001, Cola et al. 2010).

Literature References
PubMed ID Title Journal Year
11106645 Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes

Karsenty, G, Starbuck, M, Kern, B, Shen, J

J. Biol. Chem. 2001
20686481 Rb regulates fate choice and lineage commitment in vivo

Berman, SD, Quintero-Estades, JA, Calo, E, Lees, JA, Danielian, PS, Nedelcu, S

Nature 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX2:RB1:COL1A1 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX2:RB1 [nucleoplasm]
Inferred From
Col1a1 gene expression is stimulated by Runx2 and Rb1 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-04-18)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-04-18)
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