Reactome | 26S proteasome degrades TP73 polyubiquitinated by ITCH

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26S proteasome degrades TP73 polyubiquitinated by ITCH Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8957266] Orlic-Milacic, Marija, 2017-01-24
dbId	8957265
displayName	26S proteasome degrades TP73 polyubiquitinated by ITCH
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8939236] RUNX1 regulates transcription of genes involved in differentiation of HSCs - Homo sapiens
input	[Complex:R-HSA-8957254] PolyUb-TP73 tetramer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8956687] The ubiquitin-protein ligase Itch regulates p73 stability
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	26S proteasome degrades TP73 polyubiquitinated by ITCH
orthologousEvent	[BlackBoxEvent:R-DME-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Drosophila melanogaster [BlackBoxEvent:R-GGA-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Gallus gallus [BlackBoxEvent:R-XTR-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Xenopus tropicalis [BlackBoxEvent:R-DRE-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Danio rerio [BlackBoxEvent:R-SSC-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Sus scrofa [BlackBoxEvent:R-BTA-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Bos taurus [BlackBoxEvent:R-RNO-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Rattus norvegicus [BlackBoxEvent:R-MMU-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Mus musculus
output	12 × [DefinedSet:R-HSA-113595] Ub [cytosol]
precedingEvent	[Reaction:R-HSA-8956684] ITCH polyubiquitinates TP73 - Homo sapiens
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8957265
summation	[Summation:8957264] ITCH-mediated polyubiquitination of TP73 (p73) targets TP73 ...

Referrals

(hasEvent)

[Pathway:R-HSA-8939236] RUNX1 regulates transcription of genes involved in differentiation of HSCs

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