26S proteasome degrades TP73 polyubiquitinated by ITCH

Stable Identifier
R-HSA-8957265
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
26S proteasome degrades TP73 polyubiquitinated by ITCH
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ITCH-mediated polyubiquitination of TP73 (p73) targets TP73 for proteasome-mediated degradation (Rossi et al. 2005).
Literature References
PubMed ID Title Journal Year
15678106 The ubiquitin-protein ligase Itch regulates p73 stability

Rossi, M, De Laurenzi, V, Munarriz, E, Green, DR, Liu, YC, Vousden, KH, Cesareni, G, Melino, G

EMBO J. 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
26S proteasome degrades TP73 polyubiquitinated by ITCH (Bos taurus)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Danio rerio)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Drosophila melanogaster)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Gallus gallus)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Mus musculus)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Rattus norvegicus)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Sus scrofa)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Ito, Y  (2016-12-20)
Chuang, LS  (2016-12-20)
Created
Orlic-Milacic, M  (2017-01-24)
Cite Us!