Reactome | 26S proteasome degrades TP73 polyubiquitinated by ITCH

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26S proteasome degrades TP73 polyubiquitinated by ITCH Show undefined attributes

catalystActivity	[CatalystActivity:9985423] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10084225
displayName	26S proteasome degrades TP73 polyubiquitinated by ITCH
eventOf	[Pathway:R-MMU-8939236] RUNX1 regulates transcription of genes involved in differentiation of HSCs - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Homo sapiens
input	[Complex:R-MMU-8957254] PolyUb-TP73 tetramer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	26S proteasome degrades TP73 polyubiquitinated by ITCH
output	12 × [DefinedSet:R-MMU-113595] Ub [cytosol]
precedingEvent	[Reaction:R-MMU-8956684] ITCH polyubiquitinates TP73 - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-8957265
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8939236] RUNX1 regulates transcription of genes involved in differentiation of HSCs
(inferredTo)	[BlackBoxEvent:R-HSA-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH

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