RUNX1, presumably in complex with CBFB, inhibits transcripti...

created [InstanceEdit:8955884] Orlic-Milacic, Marija, 2017-01-13
dbId 8955882
displayName RUNX1, presumably in complex with CBFB, inhibits transcripti...
schemaClass Summation
text RUNX1, presumably in complex with CBFB, inhibits transcription of the SOCS3 gene. As SOCS3 is an inhibitor of STAT3, RUNX1-mediated repression of SOCS3 increases STAT3 activity, which is implicated in development of epithelial cancers (Scheitz et al. 2012).
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