Reactome | Carboxyterminal post-translational modifications of tubulin

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Carboxyterminal post-translational modifications of tubulin Show undefined attributes

authored	[InstanceEdit:8955880] D'Eustachio, Peter, 2017-01-13
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8955341] D'Eustachio, Peter, 2017-01-10
dbId	8955332
displayName	Carboxyterminal post-translational modifications of tubulin
edited	[InstanceEdit:8956248] Jupe, Steve, 2017-01-18
eventOf	[Pathway:R-HSA-597592] Post-translational protein modification - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:258214] post-translational protein modification
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-8865774] TTLLs polyglutamylate tubulin - Homo sapiens [Reaction:R-HSA-8955869] Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin - Homo sapiens [Reaction:R-HSA-8867370] TTLL3, TTLL8, TTLL10 polyglycylate tubulin - Homo sapiens [Reaction:R-HSA-8866105] CCPs deglutamylate tubulin - Homo sapiens [Reaction:R-HSA-8955706] TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin - Homo sapiens [Reaction:R-HSA-8955712] SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-12-07
literatureReference	[LiteratureReference:8866085] Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function [LiteratureReference:8955329] Post-translational modifications of tubulin: pathways to functional diversity of microtubules [LiteratureReference:8955330] Writing and Reading the Tubulin Code
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Carboxyterminal post-translational modifications of tubulin
orthologousEvent	[Pathway:R-PFA-8955332] Carboxyterminal post-translational modifications of tubulin - Plasmodium falciparum [Pathway:R-DDI-8955332] Carboxyterminal post-translational modifications of tubulin - Dictyostelium discoideum [Pathway:R-XTR-8955332] Carboxyterminal post-translational modifications of tubulin - Xenopus tropicalis [Pathway:R-SSC-8955332] Carboxyterminal post-translational modifications of tubulin - Sus scrofa [Pathway:R-CFA-8955332] Carboxyterminal post-translational modifications of tubulin - Canis familiaris [Pathway:R-RNO-8955332] Carboxyterminal post-translational modifications of tubulin - Rattus norvegicus [Pathway:R-MMU-8955332] Carboxyterminal post-translational modifications of tubulin - Mus musculus
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8956247] Jassal, Bijay, 2017-01-18
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8955332
summation	[Summation:8955872] Tubulins fold into compact globular domains with less struct...
updateTrackers	[UpdateTracker:9780979] Update Tracker - [Pathway:8955332] Carboxyterminal post-translational modifications of tubulin - v61:[updateContainedRLE] [UpdateTracker:9776607] Update Tracker - [Pathway:8955332] Carboxyterminal post-translational modifications of tubulin - v75:[updateContainedRLE] [UpdateTracker:9777562] Update Tracker - [Pathway:8955332] Carboxyterminal post-translational modifications of tubulin - v70:[updateContainedRLE]

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[Pathway:R-HSA-597592] Post-translational protein modification

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