Reactome | Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin

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Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin Show undefined attributes

authored	[InstanceEdit:8955880] D'Eustachio, Peter, 2017-01-13
catalystActivity	[CatalystActivity:8955865] tubulin-glutamic acid ligase activity of polyglutamylase complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8955871] D'Eustachio, Peter, 2017-01-13
dbId	8955869
displayName	Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin
edited	[InstanceEdit:8956248] Jupe, Steve, 2017-01-18
eventOf	[Pathway:R-HSA-8955332] Carboxyterminal post-translational modifications of tubulin - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2677] protein polyglutamylation
inferredFrom	[Reaction:R-NUL-8955873] Polyglutamylase complex (Ttll1) polyglutamylates alpha subunits of tubulin - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [Complex:R-HSA-190599] Microtubule [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8866085] Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function [LiteratureReference:8866060] Tubulin polyglutamylase enzymes are members of the TTL domain protein family
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-HSA-8982724] Polyglutamylated microtubule [cytosol]
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8956247] Jassal, Bijay, 2017-01-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8955869
summation	[Summation:8955867] Polyglutamylase complex polyglutamylates alpha subunits of t...

Referrals

(hasEvent)	[Pathway:R-HSA-8955332] Carboxyterminal post-translational modifications of tubulin
(inferredTo)	[Reaction:R-NUL-8955873] Polyglutamylase complex (Ttll1) polyglutamylates alpha subunits of tubulin

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