Reactome | CCPs deglutamylate tubulin

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CCPs deglutamylate tubulin Show undefined attributes

authored	[InstanceEdit:8956248] Jupe, Steve, 2017-01-18
catalystActivity	[CatalystActivity:8866087] metallocarboxypeptidase activity of CCPs [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8866122] Jupe, Steve, 2016-03-29
dbId	8866105
displayName	CCPs deglutamylate tubulin
edited	[InstanceEdit:8954333] D'Eustachio, Peter, 2017-01-06
eventOf	[Pathway:R-HSA-8955332] Carboxyterminal post-translational modifications of tubulin - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:1042460] protein side chain deglutamylation
inferredFrom	[Reaction:R-NUL-8867463] Ccps deglutamylate tubulin - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-8982724] Polyglutamylated microtubule [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8866109] A novel subfamily of mouse cytosolic carboxypeptidases [LiteratureReference:8866126] Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs) [LiteratureReference:8866046] Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily [LiteratureReference:8866123] A family of protein-deglutamylating enzymes associated with neurodegeneration [LiteratureReference:8954332] The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CCPs deglutamylate tubulin
output	[SimpleEntity:R-ALL-29404] L-Glu [cytosol] [Complex:R-HSA-190599] Microtubule [cytosol]
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8956247] Jassal, Bijay, 2017-01-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8866105
summation	[Summation:8954338] Cytosolic carboxypeptidases (CCPs) catalyze the removal of g...
updateTrackers	[UpdateTracker:9776567] Update Tracker - [Reaction:8866105] CCPs deglutamylate tubulin - v75:[modifyText] [UpdateTracker:9781179] Update Tracker - [Reaction:8866105] CCPs deglutamylate tubulin - v61:[add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776567] Update Tracker - [Reaction:8866105] CCPs deglutamylate tubulin - v75:[modifyText] [UpdateTracker:9781179] Update Tracker - [Reaction:8866105] CCPs deglutamylate tubulin - v61:[add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-8955332] Carboxyterminal post-translational modifications of tubulin
(inferredTo)	[Reaction:R-NUL-8867463] Ccps deglutamylate tubulin