Reactome | CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus

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CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10084051
displayName	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus
eventOf	[Pathway:R-MMU-8951664] Neddylation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex - Mus musculus
inferredFrom	[Reaction:R-HSA-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-8955089] Cand1 [nucleoplasm] [Complex:R-MMU-976149] RBX1:CUL4:DDB1:DCAFs [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus
output	[Complex:R-MMU-8955244] CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8955245
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8951664] Neddylation
(precedingEvent)	[Reaction:R-MMU-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex
(inferredTo)	[Reaction:R-HSA-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus

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