Reactome | NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP

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NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP Show undefined attributes

authored	[InstanceEdit:8954474] Jassal, Bijay, 2017-01-09
catalystActivity	[CatalystActivity:8954465] L-aspartate N-acetyltransferase activity of NAT8L [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:8954474] Jassal, Bijay, 2017-01-09
crossReference	[DatabaseIdentifier:12667531] RHEA:14166 [DatabaseIdentifier:9925771] RHEA:14166
dbId	8954468
displayName	NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP
edited	[InstanceEdit:8954474] Jassal, Bijay, 2017-01-09
eventOf	[Pathway:R-HSA-8963693] Aspartate and asparagine metabolism - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8954513] NAASP translocates from mitochondrial matrix to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113553] L-Asp [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8954489] Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia [LiteratureReference:8954480] NAT8L (N-acetyltransferase 8-like) accelerates lipid turnover and increases energy expenditure in brown adipocytes [LiteratureReference:8954493] N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP acetyl-CoA + L-aspartate => CoA + H(+) + N-acetyl-L-aspartate
orthologousEvent	[Reaction:R-PFA-8954468] NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP - Plasmodium falciparum [Reaction:R-DDI-8954468] NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP - Dictyostelium discoideum [Reaction:R-DME-8954468] NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP - Drosophila melanogaster [Reaction:R-GGA-8954468] NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP - Gallus gallus [Reaction:R-XTR-8954468] NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP - Xenopus tropicalis [Reaction:R-DRE-8954468] NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP - Danio rerio [Reaction:R-SSC-8954468] NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP - Sus scrofa [Reaction:R-CFA-8954468] NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP - Canis familiaris [Reaction:R-RNO-8954468] NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP - Rattus norvegicus [Reaction:R-MMU-8954468] NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP - Mus musculus
output	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-8954466] NAASP [mitochondrial matrix]
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8955387] D'Eustachio, Peter, 2017-01-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8954468
summation	[Summation:8954479] N-acetylaspartate (NAA) is a highly abundant brain metabolit...

Referrals

(hasEvent)	[Pathway:R-HSA-8963693] Aspartate and asparagine metabolism
(precedingEvent)	[BlackBoxEvent:R-HSA-8954513] NAASP translocates from mitochondrial matrix to cytosol