NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA

Stable Identifier
R-HSA-8954468
Type
Reaction
Species
Homo sapiens
Compartment
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N-acetylaspartate (NAA) is a highly abundant brain metabolite which delivers the acetate moiety for synthesis of acetyl-CoA, further utilised for fatty acid generation. In the mitochondrial matrix of neuronal cells, N-acetylaspartate synthetase (NAT8L) catalyses the formation of NAA from acetyl-CoA (Ac-CoA) and L-aspartatic acid (L-Asp) (Wiame et al. 2009, Pessentheiner et al. 2013, Prokesch et al. 2016).

Literature References
PubMed ID Title Journal Year
24155240 NAT8L (N-acetyltransferase 8-like) accelerates lipid turnover and increases energy expenditure in brown adipocytes

Uno, K, Groschner, LN, Bogner-Strauss, JG, Kolb, D, Miyazaki, T, Schweiger, M, Pessentheiner, AR, Walenta, E, Prokesch, A, Pelzmann, HJ, Nitta, A, Graier, WF, Rieder, D

J. Biol. Chem. 2013
27045997 N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes

Pospisilik, JA, Schittmayer, M, Drougard, A, Pessentheiner, AR, Birner-Gruenberger, R, Pelzmann, HJ, Bogner-Strauss, JG, Huber, K, Kolb, D, Madreiter-Sokolowski, CT, Graier, WF, Prokesch, A, Magnes, C, Trausinger, G

Sci Rep 2016
19807691 Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia

Courtoy, PJ, Pierrot, N, Collard, F, Wiame, E, Vincent, MF, Noel, G, Tyteca, D, Amyere, M, Desmedt, J, Boltshauser, E, Vikkula, M, Van Schaftingen, E, Octave, JN, Nassogne, MC

Biochem. J. 2009
Participants
Participates
Catalyst Activity

aspartate N-acetyltransferase activity of NAT8L [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
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