N-acetylaspartate (NAA) is a highly abundant brain metabolite which delivers the acetate moiety for synthesis of acetyl-CoA, further utilised for fatty acid generation. In the mitochondrial matrix of neuronal cells, N-acetylaspartate synthetase (NAT8L) catalyses the formation of NAA from acetyl-CoA (Ac-CoA) and L-aspartatic acid (L-Asp) (Wiame et al. 2009, Pessentheiner et al. 2013, Prokesch et al. 2016).
Prokesch, A, Pelzmann, HJ, Pessentheiner, AR, Huber, K, Madreiter-Sokolowski, CT, Drougard, A, Schittmayer, M, Kolb, D, Magnes, C, Trausinger, G, Graier, WF, Birner-Gruenberger, R, Pospisilik, JA, Bogner-Strauss, JG
Pessentheiner, AR, Pelzmann, HJ, Walenta, E, Schweiger, M, Groschner, LN, Graier, WF, Kolb, D, Uno, K, Miyazaki, T, Nitta, A, Rieder, D, Prokesch, A, Bogner-Strauss, JG
Wiame, E, Tyteca, D, Pierrot, N, Collard, F, Amyere, M, Noel, G, Desmedt, J, Nassogne, MC, Vikkula, M, Octave, JN, Vincent, MF, Courtoy, PJ, Boltshauser, E, Van Schaftingen, E
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