NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

N-acetylaspartate (NAA) is a highly abundant brain metabolite which delivers the acetate moiety for synthesis of acetyl-CoA, further utilised for fatty acid generation. In the mitochondrial matrix of neuronal cells, N-acetylaspartate synthetase (NAT8L) catalyses the formation of NAA from acetyl-CoA (Ac-CoA) and L-aspartatic acid (L-Asp) (Wiame et al. 2009, Pessentheiner et al. 2013, Prokesch et al. 2016).

Literature References
PubMed ID Title Journal Year
24155240 NAT8L (N-acetyltransferase 8-like) accelerates lipid turnover and increases energy expenditure in brown adipocytes

Uno, K, Groschner, LN, Bogner-Strauss, JG, Kolb, D, Miyazaki, T, Schweiger, M, Pessentheiner, AR, Walenta, E, Prokesch, A, Pelzmann, HJ, Nitta, A, Graier, WF, Rieder, D

J. Biol. Chem. 2013
27045997 N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes

Pospisilik, JA, Schittmayer, M, Drougard, A, Pessentheiner, AR, Birner-Gruenberger, R, Pelzmann, HJ, Bogner-Strauss, JG, Huber, K, Kolb, D, Madreiter-Sokolowski, CT, Graier, WF, Prokesch, A, Magnes, C, Trausinger, G

Sci Rep 2016
19807691 Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia

Courtoy, PJ, Pierrot, N, Collard, F, Wiame, E, Vincent, MF, Noel, G, Tyteca, D, Amyere, M, Desmedt, J, Boltshauser, E, Vikkula, M, Van Schaftingen, E, Octave, JN, Nassogne, MC

Biochem. J. 2009
Catalyst Activity

aspartate N-acetyltransferase activity of NAT8L [mitochondrial matrix]

Orthologous Events
Cross References
Cite Us!