Reactome | NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA

NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA

Stable Identifier

R-HSA-8954468

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

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NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA

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N-acetylaspartate (NAA) is a highly abundant brain metabolite which delivers the acetate moiety for synthesis of acetyl-CoA, further utilised for fatty acid generation. In the mitochondrial matrix of neuronal cells, N-acetylaspartate synthetase (NAT8L) catalyses the formation of NAA from acetyl-CoA (Ac-CoA) and L-aspartatic acid (L-Asp) (Wiame et al. 2009, Pessentheiner et al. 2013, Prokesch et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
27045997	N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes Prokesch, A, Pelzmann, HJ, Pessentheiner, AR, Huber, K, Madreiter-Sokolowski, CT, Drougard, A, Schittmayer, M, Kolb, D, Magnes, C, Trausinger, G, Graier, WF, Birner-Gruenberger, R, Pospisilik, JA, Bogner-Strauss, JG	Sci Rep	2016
24155240	NAT8L (N-acetyltransferase 8-like) accelerates lipid turnover and increases energy expenditure in brown adipocytes Pessentheiner, AR, Pelzmann, HJ, Walenta, E, Schweiger, M, Groschner, LN, Graier, WF, Kolb, D, Uno, K, Miyazaki, T, Nitta, A, Rieder, D, Prokesch, A, Bogner-Strauss, JG	J. Biol. Chem.	2013
19807691	Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia Wiame, E, Tyteca, D, Pierrot, N, Collard, F, Amyere, M, Noel, G, Desmedt, J, Nassogne, MC, Vikkula, M, Octave, JN, Vincent, MF, Courtoy, PJ, Boltshauser, E, Van Schaftingen, E	Biochem. J.	2009