Reactome | DNPH1 hydrolyses dGMP

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DNPH1 hydrolyses dGMP Show undefined attributes

authored	[InstanceEdit:8953386] Jassal, Bijay, 2016-12-22
catalystActivity	[CatalystActivity:8953366] 5-hydroxymethyl-dUMP N-hydrolase activity of DNPH1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8953361] Jassal, Bijay, 2016-12-22
crossReference	[DatabaseIdentifier:12667778] RHEA:57817 [DatabaseIdentifier:9976354] RHEA:57817
dbId	8953339
displayName	DNPH1 hydrolyses dGMP
edited	[InstanceEdit:8953386] Jassal, Bijay, 2016-12-22
eventOf	[Pathway:R-HSA-74259] Purine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-74255] Guanine + H2O => Xanthine + NH4+ - Homo sapiens
input	[SimpleEntity:R-ALL-109327] dGMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8953363] N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1 [LiteratureReference:8953365] The c-Myc target gene Rcl (C6orf108) encodes a novel enzyme, deoxynucleoside 5'-monophosphate N-glycosidase [LiteratureReference:8953335] 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	DNPH1 hydrolyses dGMP dGMP + H2O => 2-deoxy-D-ribose 5-phosphate + guanine
orthologousEvent	[Reaction:R-DRE-8953339] DNPH1 hydrolyses dGMP - Danio rerio [Reaction:R-SSC-8953339] DNPH1 hydrolyses dGMP - Sus scrofa [Reaction:R-BTA-8953339] DNPH1 hydrolyses dGMP - Bos taurus [Reaction:R-CFA-8953339] DNPH1 hydrolyses dGMP - Canis familiaris [Reaction:R-RNO-8953339] DNPH1 hydrolyses dGMP - Rattus norvegicus [Reaction:R-MMU-8953339] DNPH1 hydrolyses dGMP - Mus musculus
output	[SimpleEntity:R-ALL-8953344] 2DORP [cytosol] [SimpleEntity:R-ALL-83956] Gua [cytosol]
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8954302] D'Eustachio, Peter, 2017-01-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8953339
summation	[Summation:8953359] 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (DNPH1 aka c-M...

Referrals

(hasEvent)	[Pathway:R-HSA-74259] Purine catabolism
(precedingEvent)	[Reaction:R-HSA-74255] Guanine + H2O => Xanthine + NH4+

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