Reactome | Guanine + H2O => Xanthine + NH4+

Schema > Reaction > Entries

Guanine + H2O => Xanthine + NH4+ Show undefined attributes

catalystActivity	[CatalystActivity:74254] guanine deaminase activity of GDA dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643099] guanine deaminase activity of GDA dimer [cytosol] Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein.
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference	[DatabaseIdentifier:12667777] RHEA:14666 [DatabaseIdentifier:9976359] RHEA:14666
dbId	74255
displayName	Guanine + H2O => Xanthine + NH4+
eventOf	[Pathway:R-HSA-74259] Purine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-74258] XDH oxidizes xanthine to form urate - Homo sapiens [Reaction:R-HSA-9727349] XDH dehydrogenates xanthine to form urate - Homo sapiens
input	[SimpleEntity:R-ALL-83956] Gua [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200117] Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein. [LiteratureReference:500137] Alteration of enzyme specificity by computational loop remodeling and design
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Guanine + H2O => Xanthine + NH4+ guanine + H2O + H(+) => xanthine + NH4(+)
orthologousEvent	[Reaction:R-SCE-74255] Guanine + H2O => Xanthine + NH4+ - Saccharomyces cerevisiae [Reaction:R-SPO-74255] Guanine + H2O => Xanthine + NH4+ - Schizosaccharomyces pombe [Reaction:R-DDI-74255] Guanine + H2O => Xanthine + NH4+ - Dictyostelium discoideum [Reaction:R-DME-74255] Guanine + H2O => Xanthine + NH4+ - Drosophila melanogaster [Reaction:R-GGA-74255] Guanine + H2O => Xanthine + NH4+ - Gallus gallus [Reaction:R-XTR-74255] Guanine + H2O => Xanthine + NH4+ - Xenopus tropicalis [Reaction:R-DRE-74255] Guanine + H2O => Xanthine + NH4+ - Danio rerio [Reaction:R-SSC-74255] Guanine + H2O => Xanthine + NH4+ - Sus scrofa [Reaction:R-BTA-74255] Guanine + H2O => Xanthine + NH4+ - Bos taurus [Reaction:R-CFA-74255] Guanine + H2O => Xanthine + NH4+ - Canis familiaris [Reaction:R-RNO-74255] Guanine + H2O => Xanthine + NH4+ - Rattus norvegicus [Reaction:R-MMU-74255] Guanine + H2O => Xanthine + NH4+ - Mus musculus
output	[SimpleEntity:R-ALL-31633] NH4+ [cytosol] [SimpleEntity:R-ALL-30064] XAN [cytosol]
precedingEvent	[Reaction:R-HSA-74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose - Homo sapiens [Reaction:R-HSA-8953339] DNPH1 hydrolyses dGMP - Homo sapiens [FailedReaction:R-HSA-9734274] Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74255
summation	[Summation:178834] Cytosolic guanine deaminase (GDA) catalyzes the reaction of ...
updateTrackers	[UpdateTracker:9792381] Update Tracker - [Reaction:74255] Guanine + H2O => Xanthine + NH4+ - v22:[addLiteratureReference] [UpdateTracker:9791142] Update Tracker - [Reaction:74255] Guanine + H2O => Xanthine + NH4+ - v32:[addLiteratureReference, modifyText] [UpdateTracker:9775912] Update Tracker - [Reaction:74255] Guanine + H2O => Xanthine + NH4+ - v78:[addInput] [UpdateTracker:9781613] Update Tracker - [Reaction:74255] Guanine + H2O => Xanthine + NH4+ - v60:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9792381] Update Tracker - [Reaction:74255] Guanine + H2O => Xanthine + NH4+ - v22:[addLiteratureReference] [UpdateTracker:9791142] Update Tracker - [Reaction:74255] Guanine + H2O => Xanthine + NH4+ - v32:[addLiteratureReference, modifyText] [UpdateTracker:9775912] Update Tracker - [Reaction:74255] Guanine + H2O => Xanthine + NH4+ - v78:[addInput] [UpdateTracker:9781613] Update Tracker - [Reaction:74255] Guanine + H2O => Xanthine + NH4+ - v60:[add_removeOutput]
(precedingEvent)	[Reaction:R-HSA-74258] XDH oxidizes xanthine to form urate [Reaction:R-HSA-9727349] XDH dehydrogenates xanthine to form urate
(hasEvent)	[Pathway:R-HSA-74259] Purine catabolism

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