Reactome | MECR dimer reduces tdec2-CoA to DEC-CoA

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MECR dimer reduces tdec2-CoA to DEC-CoA Show undefined attributes

authored	[InstanceEdit:8952867] Jassal, Bijay, 2016-12-20
catalystActivity	[CatalystActivity:8952869] trans-2-enoyl-CoA reductase (NADPH) activity of MECR dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:8952867] Jassal, Bijay, 2016-12-20
crossReference	[DatabaseIdentifier:12667836] RHEA:44961
dbId	8952873
displayName	MECR dimer reduces tdec2-CoA to DEC-CoA
edited	[InstanceEdit:8952867] Jassal, Bijay, 2016-12-20
eventOf	[Pathway:R-HSA-77346] Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-77343] tdec2-CoA [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8952871] Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties [LiteratureReference:8952868] Characterization of 2-enoyl thioester reductase from mammals. An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	MECR dimer reduces tdec2-CoA to DEC-CoA
orthologousEvent	[Reaction:R-CFA-8952873] MECR dimer reduces tdec2-CoA to DEC-CoA - Canis familiaris [Reaction:R-SCE-8952873] MECR dimer reduces tdec2-CoA to DEC-CoA - Saccharomyces cerevisiae [Reaction:R-SPO-8952873] MECR dimer reduces tdec2-CoA to DEC-CoA - Schizosaccharomyces pombe [Reaction:R-DDI-8952873] MECR dimer reduces tdec2-CoA to DEC-CoA - Dictyostelium discoideum [Reaction:R-CEL-8952873] MECR dimer reduces tdec2-CoA to DEC-CoA - Caenorhabditis elegans [Reaction:R-DME-8952873] MECR dimer reduces tdec2-CoA to DEC-CoA - Drosophila melanogaster [Reaction:R-GGA-8952873] MECR dimer reduces tdec2-CoA to DEC-CoA - Gallus gallus [Reaction:R-XTR-8952873] MECR dimer reduces tdec2-CoA to DEC-CoA - Xenopus tropicalis [Reaction:R-DRE-8952873] MECR dimer reduces tdec2-CoA to DEC-CoA - Danio rerio [Reaction:R-SSC-8952873] MECR dimer reduces tdec2-CoA to DEC-CoA - Sus scrofa [Reaction:R-BTA-8952873] MECR dimer reduces tdec2-CoA to DEC-CoA - Bos taurus [Reaction:R-RNO-8952873] MECR dimer reduces tdec2-CoA to DEC-CoA - Rattus norvegicus [Reaction:R-MMU-8952873] MECR dimer reduces tdec2-CoA to DEC-CoA - Mus musculus
output	[SimpleEntity:R-ALL-77308] DEC-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-109998] Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8954302] D'Eustachio, Peter, 2017-01-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8952873
summation	[Summation:8952861] Mitochondrial trans-2-enoyl-CoA reductase (MECR aka NBRF1) i...

Referrals

(hasEvent)

[Pathway:R-HSA-77346] Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA

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