MECR dimer reduces tdec2-CoA to DEC-CoA

Stable Identifier
R-HSA-8952873
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mitochondrial trans-2-enoyl-CoA reductase (MECR aka NBRF1) is a dimeric oxidoreductase with a preference for short and medium chain trans fatty acyl-CoA substrates and may play a role in mitochondrial fatty acid synthesis (Chen et al. 2008). MECR is able to reduce trans acyl-CoA substrates of chain length C6 to C16 in an NADPH-dependent manner (Miinalainen et al. 2003). A representative reaction described here is the reduction of trans-dec-2-enoyl-CoA (tdec2-CoA) to decanoyl-CoA (DEC-CoA).

Literature References
PubMed ID Title Journal Year
18479707 Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties

Pudas, R, Sharma, S, Juffer, AH, Haapalainen, AM, Smart, OS, Chen, ZJ, Wierenga, RK, Hiltunen, JK

J. Mol. Biol. 2008
12654921 Characterization of 2-enoyl thioester reductase from mammals. An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II

Qin, YM, Bergmann, U, Torkko, JM, Chen, ZJ, Miinalainen, IJ, Pirilä, PL, Hiltunen, JK, Sormunen, RT

J. Biol. Chem. 2003
Participants
Participates
Catalyst Activity

trans-2-enoyl-CoA reductase (NADPH) activity of MECR dimer [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!