Mitochondrial trans-2-enoyl-CoA reductase (MECR aka NBRF1) is a dimeric oxidoreductase with a preference for short and medium chain trans fatty acyl-CoA substrates and may play a role in mitochondrial fatty acid synthesis (Chen et al. 2008). MECR is able to reduce trans acyl-CoA substrates of chain length C6 to C16 in an NADPH-dependent manner (Miinalainen et al. 2003). A representative reaction described here is the reduction of trans-dec-2-enoyl-CoA (tdec2-CoA) to decanoyl-CoA (DEC-CoA).
Pudas, R, Sharma, S, Juffer, AH, Haapalainen, AM, Smart, OS, Chen, ZJ, Wierenga, RK, Hiltunen, JK
Qin, YM, Bergmann, U, Torkko, JM, Chen, ZJ, Miinalainen, IJ, Pirilä, PL, Hiltunen, JK, Sormunen, RT
trans-2-enoyl-CoA reductase (NADPH) activity of MECR dimer [mitochondrial matrix]
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