MECR dimer reduces tdec2-CoA to DEC-CoA

Stable Identifier
R-HSA-8952873
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MECR dimer reduces tdec2-CoA to DEC-CoA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mitochondrial trans-2-enoyl-CoA reductase (MECR aka NBRF1) is a dimeric oxidoreductase with a preference for short and medium chain trans fatty acyl-CoA substrates and may play a role in mitochondrial fatty acid synthesis (Chen et al. 2008). MECR is able to reduce trans acyl-CoA substrates of chain length C6 to C16 in an NADPH-dependent manner (Miinalainen et al. 2003). A representative reaction described here is the reduction of trans-dec-2-enoyl-CoA (tdec2-CoA) to decanoyl-CoA (DEC-CoA).

Literature References
PubMed ID Title Journal Year
12654921 Characterization of 2-enoyl thioester reductase from mammals. An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II

Miinalainen, IJ, Chen, ZJ, Torkko, JM, Pirilä, PL, Sormunen, RT, Bergmann, U, Qin, YM, Hiltunen, JK

J. Biol. Chem. 2003
18479707 Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties

Chen, ZJ, Pudas, R, Sharma, S, Smart, OS, Juffer, AH, Hiltunen, JK, Wierenga, RK, Haapalainen, AM

J. Mol. Biol. 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
trans-2-enoyl-CoA reductase (NADPH) activity of MECR dimer [mitochondrial matrix]
Physical Entity
MECR dimer [mitochondrial matrix]
Activity
trans-2-enoyl-CoA reductase (NADPH) activity (0019166)
Orthologous Events
MECR dimer reduces tdec2-CoA to DEC-CoA (Bos taurus)
MECR dimer reduces tdec2-CoA to DEC-CoA (Caenorhabditis elegans)
MECR dimer reduces tdec2-CoA to DEC-CoA (Canis familiaris)
MECR dimer reduces tdec2-CoA to DEC-CoA (Danio rerio)
MECR dimer reduces tdec2-CoA to DEC-CoA (Dictyostelium discoideum)
MECR dimer reduces tdec2-CoA to DEC-CoA (Drosophila melanogaster)
MECR dimer reduces tdec2-CoA to DEC-CoA (Gallus gallus)
MECR dimer reduces tdec2-CoA to DEC-CoA (Mus musculus)
MECR dimer reduces tdec2-CoA to DEC-CoA (Rattus norvegicus)
MECR dimer reduces tdec2-CoA to DEC-CoA (Saccharomyces cerevisiae)
MECR dimer reduces tdec2-CoA to DEC-CoA (Schizosaccharomyces pombe)
MECR dimer reduces tdec2-CoA to DEC-CoA (Sus scrofa)
MECR dimer reduces tdec2-CoA to DEC-CoA (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2016-12-20)
Reviewed
D'Eustachio, P  (2017-01-06)
Created
Jassal, B  (2016-12-20)