Mitochondrial trans-2-enoyl-CoA reductase (MECR aka NBRF1) is a dimeric oxidoreductase with a preference for short and medium chain trans fatty acyl-CoA substrates and may play a role in mitochondrial fatty acid synthesis (Chen et al. 2008). MECR is able to reduce trans acyl-CoA substrates of chain length C6 to C16 in an NADPH-dependent manner (Miinalainen et al. 2003). A representative reaction described here is the reduction of trans-dec-2-enoyl-CoA (tdec2-CoA) to decanoyl-CoA (DEC-CoA).
Miinalainen, IJ, Chen, ZJ, Torkko, JM, Pirilä, PL, Sormunen, RT, Bergmann, U, Qin, YM, Hiltunen, JK
Chen, ZJ, Pudas, R, Sharma, S, Smart, OS, Juffer, AH, Hiltunen, JK, Wierenga, RK, Haapalainen, AM
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