MECR dimer reduces tdec2-CoA to DEC-CoA

Stable Identifier
R-HSA-8952873
Type
Reaction
Species
Homo sapiens
Compartment
mitochondrial matrix
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MECR dimer reduces tdec2-CoA to DEC-CoA
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Mitochondrial trans-2-enoyl-CoA reductase (MECR aka NBRF1) is a dimeric oxidoreductase with a preference for short and medium chain trans fatty acyl-CoA substrates and may play a role in mitochondrial fatty acid synthesis (Chen et al. 2008). MECR is able to reduce trans acyl-CoA substrates of chain length C6 to C16 in an NADPH-dependent manner (Miinalainen et al. 2003). A representative reaction described here is the reduction of trans-dec-2-enoyl-CoA (tdec2-CoA) to decanoyl-CoA (DEC-CoA).

Literature References
PubMed ID Title Journal Year
18479707 Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties

Pudas, R, Sharma, S, Juffer, AH, Haapalainen, AM, Smart, OS, Chen, ZJ, Wierenga, RK, Hiltunen, JK

J. Mol. Biol. 2008
12654921 Characterization of 2-enoyl thioester reductase from mammals. An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II

Qin, YM, Bergmann, U, Torkko, JM, Chen, ZJ, Miinalainen, IJ, Pirilä, PL, Hiltunen, JK, Sormunen, RT

J. Biol. Chem. 2003
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as an event of
Catalyst Activity

trans-2-enoyl-CoA reductase (NADPH) activity of MECR dimer [mitochondrial matrix]

Physical Entity
MECR dimer [mitochondrial matrix] (Homo sapiens)
Activity
trans-2-enoyl-CoA reductase (NADPH) activity (GO:0019166)
Orthologous Events
MECR dimer reduces tdec2-CoA to DEC-CoA (Caenorhabditis elegans)
MECR dimer reduces tdec2-CoA to DEC-CoA (Canis familiaris)
MECR dimer reduces tdec2-CoA to DEC-CoA (Danio rerio)
MECR dimer reduces tdec2-CoA to DEC-CoA (Dictyostelium discoideum)
MECR dimer reduces tdec2-CoA to DEC-CoA (Drosophila melanogaster)
MECR dimer reduces tdec2-CoA to DEC-CoA (Gallus gallus)
MECR dimer reduces tdec2-CoA to DEC-CoA (Mus musculus)
MECR dimer reduces tdec2-CoA to DEC-CoA (Rattus norvegicus)
MECR dimer reduces tdec2-CoA to DEC-CoA (Saccharomyces cerevisiae)
MECR dimer reduces tdec2-CoA to DEC-CoA (Schizosaccharomyces pombe)
MECR dimer reduces tdec2-CoA to DEC-CoA (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2016-12-20)
Reviewed
D'Eustachio, P  (2017-01-06)
Created
Jassal, B  (2016-12-20)
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