Reactome | FAM20C phosphorylates FAM20C substrates

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FAM20C phosphorylates FAM20C substrates Show undefined attributes

authored	[InstanceEdit:8952286] Jupe, Steve, 2016-12-14
catalystActivity	[CatalystActivity:8952283] protein serine/threonine kinase activity of FAM20C:FAM20C substrates [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:8952286] Jupe, Steve, 2016-12-14
dbId	8952289
displayName	FAM20C phosphorylates FAM20C substrates
edited	[InstanceEdit:8956248] Jupe, Steve, 2017-01-18
eventOf	[Pathway:R-HSA-8957275] Post-translational protein phosphorylation - Homo sapiens [Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Homo sapiens
input	105 × [SimpleEntity:R-ALL-8931885] ATP [endoplasmic reticulum lumen] [Complex:R-HSA-8952321] FAM20C:FAM20C substrates [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8952279] A Single Kinase Generates the Majority of the Secreted Phosphoproteome
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	FAM20C phosphorylates FAM20C substrates
orthologousEvent	[Reaction:R-MMU-8952289] FAM20C phosphorylates FAM20C substrates - Mus musculus [Reaction:R-CEL-8952289] FAM20C phosphorylates FAM20C substrates - Caenorhabditis elegans [Reaction:R-DME-8952289] FAM20C phosphorylates FAM20C substrates - Drosophila melanogaster [Reaction:R-GGA-8952289] FAM20C phosphorylates FAM20C substrates - Gallus gallus [Reaction:R-XTR-8952289] FAM20C phosphorylates FAM20C substrates - Xenopus tropicalis [Reaction:R-DRE-8952289] FAM20C phosphorylates FAM20C substrates - Danio rerio [Reaction:R-SSC-8952289] FAM20C phosphorylates FAM20C substrates - Sus scrofa [Reaction:R-BTA-8952289] FAM20C phosphorylates FAM20C substrates - Bos taurus [Reaction:R-CFA-8952289] FAM20C phosphorylates FAM20C substrates - Canis familiaris [Reaction:R-RNO-8952289] FAM20C phosphorylates FAM20C substrates - Rattus norvegicus
output	105 × [SimpleEntity:R-ALL-8931884] ADP [endoplasmic reticulum lumen] [Complex:R-HSA-8952335] FAM20C:Phosphorylated FAM20C substrates [endoplasmic reticulum lumen]
regulatedBy	[PositiveRegulation:R-HSA-8957345] Positive regulation by 'FAM20C:FAM20A [endoplasmic reticulum lumen]'
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8956488] Wiley, Sandra E, 2017-01-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8952289
summation	[Summation:8952326] Extracellular serine/threonine protein kinase FAM20C is an e...

Referrals

(hasEvent)

[Pathway:R-HSA-8957275] Post-translational protein phosphorylation
[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)