FAM20C phosphorylates FAM20C substrates

Stable Identifier
R-HSA-8952289
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Extracellular serine/threonine protein kinase FAM20C is an extracellular kinase that can phosphorylate a broad range of secreted protein. FAM20C is bound and allosterically activated by the pseudokinase FAM20A (Tagliabracchi et al. 2012, 2015, Cui et al. 2015).
Loss of function mutations in Fam20C cause Raine Syndrome, an osteosclerotic bone dysplasia (Faundes et al. 2014).

Literature References
PubMed ID Title Journal Year
26091039 A Single Kinase Generates the Majority of the Secreted Phosphoproteome

Tagliabracci, VS, Wiley, SE, Guo, X, Kinch, LN, Durrant, E, Wen, J, Xiao, J, Cui, J, Nguyen, KB, Engel, JL, Coon, JJ, Grishin, N, Pinna, LA, Pagliarini, DJ, Dixon, JE

Cell 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of FAM20C:FAM20C substrates [endoplasmic reticulum lumen]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created