p-S13-FUNDC1 is dephosphorylated by PGAM5

Stable Identifier
R-HSA-8948139
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Mitochondria are selectively removed by interactions between LC3 and the FUNDC1 mitophagy receptor which harbors an LC3-interacting region (LIR). When mitochondrial stresses are sensed mitochondrially localized PGAM5 phosphatase interacts with and dephosphorylates FUNDC1 at serine 13 (Ser-13) upon hypoxia.

Literature References
PubMed ID Title Journal Year
24746696 A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy

Chen, G, Han, Z, Feng, D, Chen, Y, Chen, L, Wu, H, Huang, L, Zhou, C, Cai, X, Fu, C, Duan, L, Wang, X, Liu, L, Liu, X, Shen, Y, Zhu, Y, Chen, Q

Mol. Cell 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PGAM5-S [mitochondrial outer membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created