mTORC1 phosphorylates MAF1

Stable Identifier
R-HSA-8944454
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Activated mTORC1 complex phosphorylates the transcription factor MAF1 on serine residues S60, S68 and S75 (Shor et al. 2010, Michels et al. 2010). mTORC1-mediated phosphorylation of MAF1 inhibits translocation of MAF1 to the nucleus (Shor et al. 2010).
Literature References
PubMed ID Title Journal Year
20516213 mTORC1 directly phosphorylates and regulates human MAF1

Robitaille, AM, Buczynski-Ruchonnet, D, Hall, MN, Hodroj, W, Hernandez, N, Reina, JH, Michels, AA

Mol. Cell. Biol. 2010
20233713 Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells

Yu, K, Follettie, M, Toral-Barza, L, Shakey, Q, Wu, J, Shor, B, Shi, C

J. Biol. Chem. 2010
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]

Orthologous Events
Authored
Created
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