mTORC1 phosphorylates MAF1

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R-HSA-8944454
Type
Reaction [transition]
Species
Homo sapiens
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Activated mTORC1 complex phosphorylates the transcription factor MAF1 on serine residues S60, S68 and S75 (Shor et al. 2010, Michels et al. 2010). mTORC1-mediated phosphorylation of MAF1 inhibits translocation of MAF1 to the nucleus (Shor et al. 2010).

Literature References
PubMed ID Title Journal Year
20233713 Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells

Shor, B, Wu, J, Shakey, Q, Toral-Barza, L, Shi, C, Follettie, M, Yu, K

J. Biol. Chem. 2010
20516213 mTORC1 directly phosphorylates and regulates human MAF1

Michels, AA, Robitaille, AM, Buczynski-Ruchonnet, D, Hodroj, W, Reina, JH, Hall, MN, Hernandez, N

Mol. Cell. Biol. 2010
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Catalyst Activity
Title
protein serine/threonine kinase activity of mTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]
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Activity
Orthologous Events
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Created